Tbio DSG1 Desmoglein-1

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Desmoglein-1

Protein / Cell Adhesion Molecule / Cadherin / Desmoglein-1

Protein Summary

Description

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q02413
• B7Z845

Gene Name

• DSG1

Ensembl ID

• ENST00000257192
• ENSP00000257192
• ENSG00000134760
• ENST00000462981
• ENSP00000462666

Symbol

• CDHF4
• DG1
• DSG
• CDHF4
• EPKHE
• PPKS1
• SPPK1
• EPKHIA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
interacting protein	0.98
protein domain	0.92
gene perturbation	0.76
cellular component	0.74

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 595.75   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 733   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 595.75   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 733   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (19)

Reactome (11)

KEGG (1)

WikiPathways (7)

Apoptosis (R-HSA-109581)

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Items per page:

5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Apoptotic cleavage of cell adhesion proteins	11 targets	R-HSA-351906
Reactome	Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Reactome	Apoptotic execution phase	52 targets	R-HSA-75153
Reactome	Developmental Biology	1055 targets	R-HSA-1266738

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581
Apoptotic cleavage of cell adhesion proteins	11 targets	R-HSA-351906
Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Apoptotic execution phase	52 targets	R-HSA-75153
Developmental Biology	1055 targets	R-HSA-1266738

Gene Ontology Terms (22)

Functions (3)

Components (9)

Processes (10)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
gamma-catenin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
calcium ion binding	Non-traceable Author Statement (NAS)	UniProtKB
toxic substance binding	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (112)

Explore Interacting Targets

1 – 10 of 112

• See Interactions on String-DB

CCDC51

Tdark

Novelty: 1.55555556

p_int: 0.936203192

p_ni: 0.063796808

Score: 0.175

Data Source: BioPlex,STRINGDB

PI4KA

Tchem

Family: Kinase

Novelty: 0.02976615

p_int: 0.904551138

p_ni: 0.095448862

Data Source: BioPlex

TBC1D22B

Tbio

Novelty: 6

p_int: 0.869865587

p_ni: 0.130134413

Data Source: BioPlex

VAV1

Tchem

Novelty: 0.00223848

p_int: 0.828215187

p_ni: 0.171784813

Score: 0.221

Data Source: BioPlex,STRINGDB

CFAP298

Tbio

Novelty: 0.03483309

p_int: 0.819776528

p_ni: 0.180223471

Score: 0.161

Data Source: BioPlex,STRINGDB

PKP1

Tbio

Novelty: 0.01427015

Score: 0.993

Data Source: STRINGDB

PKP2

Tbio

Novelty: 0.00658515

Score: 0.992

Data Source: STRINGDB

DSP

Tbio

Novelty: 0.00098564

Score: 0.992

Data Source: STRINGDB

PKP3

Tbio

Novelty: 0.03295269

Score: 0.991

Data Source: STRINGDB

JUP

Tbio

Novelty: 0.01122537

Score: 0.985

Data Source: STRINGDB

Publication Statistics

PubMed Score  595.75

PubMed score by year

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PubTator Score  526.2

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPI

1-70

AKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERP

70-140

LELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFI

140-210

INRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE

210-280

NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIG

280-350

VRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTT

350-420

VRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDD

420-490

RTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLV

490-560

LGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNS

560-630

GVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQ

630-700

KAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPD

700-770

LDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTES

770-840

YTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLT

840-910

IHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLV

910-980

GTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK

980-1049

MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK

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Uniprot Keyword

Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Glycoprotein
Hypotrichosis
Membrane