You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ACP2
Lysosomal acid phosphatase

Protein Summary
Description
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256997
  • ENSP00000256997
  • ENSG00000134575

Symbol
  • LAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.96
transcription factor binding site profile
0.9
cellular component
0.88
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.58   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.58   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
73.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
73.9
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (89)
1 – 10 of 89
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.999376565
p_ni: 0.000623435
Data Source: BioPlex
S1PR1
Tclin
Family: GPCR
Novelty: 0.00162513
p_int: 0.99610015
p_ni: 0.00389985
Data Source: BioPlex
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.994827726
p_ni: 0.005172273
Score: 0.162
Data Source: BioPlex,STRINGDB
LMAN2L
Tbio
Novelty: 0.04364985
p_int: 0.992791621
p_ni: 0.00720836
p_wrong: 1.8e-8
Score: 0.204
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.984881712
p_ni: 0.015118182
p_wrong: 1.05e-7
Score: 0.214
Data Source: BioPlex,STRINGDB
HTR2C
Tclin
Family: GPCR
Novelty: 0.00074287
p_int: 0.978977689
p_ni: 0.021022311
p_wrong: 1e-9
Data Source: BioPlex
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.977985694
p_ni: 0.022014306
Data Source: BioPlex
P2RY12
Tclin
Family: GPCR
Novelty: 0.00035406
p_int: 0.969291883
p_ni: 0.030708116
p_wrong: 1e-9
Data Source: BioPlex
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.961388879
p_ni: 0.038604581
p_wrong: 0.000006541
Data Source: BioPlex
ADGRG5
Tdark
Family: GPCR
Novelty: 0.26575982
p_int: 0.955218582
p_ni: 0.044781418
Data Source: BioPlex
Publication Statistics
PubMed Score  275.58

PubMed score by year
PubTator Score  54.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: