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Tbio
TRIM45
Tripartite motif-containing protein 45

Protein Summary
Description
May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256649
  • ENSP00000256649
  • ENSG00000134253
  • ENST00000369464
  • ENSP00000358476

Symbol
  • RNF99
  • RNF99
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.9
interacting protein
0.69
cell line
0.65
small molecule perturbation
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.17   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.17   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 45
VGNC:1701
457158
Macaque
tripartite motif containing 45
711397
Mouse
MGI:1918187
229644
Rat
RGD:1309168
295323
Dog
tripartite motif containing 45
VGNC:47824
475811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 45
Macaque
tripartite motif containing 45
Mouse
Rat
Dog
tripartite motif containing 45
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H8W5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (164)
1 – 10 of 164
AARSD1
Tdark
Novelty: 0.75372406
p_int: 0.99999982
p_ni: 8e-9
p_wrong: 1.73e-7
Score: 0.807
Data Source: BioPlex,STRINGDB
MGME1
Tbio
Family: Enzyme
Novelty: 0.05284418
p_int: 0.999999162
p_ni: 2.1e-8
p_wrong: 8.17e-7
Score: 0.297
Data Source: BioPlex,STRINGDB
HLA-C
Tbio
Novelty: 0.00698601
Score: 0.965
Data Source: STRINGDB
HLA-C
Tbio
Novelty: 0.00698601
Score: 0.965
Data Source: STRINGDB
HLA-C
Tbio
Novelty: 0.00698601
Score: 0.965
Data Source: STRINGDB
HLA-C
Tbio
Novelty: 0.00698601
Score: 0.965
Data Source: STRINGDB
HLA-C
Tbio
Novelty: 0.00698601
Score: 0.965
Data Source: STRINGDB
HLA-C
Tbio
Novelty: 0.00698601
Score: 0.965
Data Source: STRINGDB
HLA-C
Tbio
Novelty: 0.00698601
Score: 0.965
Data Source: STRINGDB
HLA-C
Tbio
Novelty: 0.00698601
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.17

PubMed score by year
PubTator Score  2.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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