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Tchem
NOTCH2
Neurogenic locus notch homolog protein 2

Protein Summary
Description
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256646
  • ENSP00000256646
  • ENSG00000134250

Symbol
  • hN2
  • AGS2
  • HJCYS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.99
microRNA
0.97
kinase perturbation
0.96
cellular component
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.35   (req: < 5)
Gene RIFs: 172   (req: <= 3)
Antibodies: 596   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.35   (req: >= 5)
Gene RIFs: 172   (req: > 3)
Antibodies: 596   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3410161
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (48)
Defective LFNG causes SCDO3 (R-HSA-5083630)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective LFNG causes SCDO3
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Defective LFNG causes SCDO3
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Gene expression (Transcription)
Gene Ontology Terms (34)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (212)
1 – 10 of 212
ANKRD44
Tdark
Family: Enzyme
Novelty: 0.9
p_int: 0.999991275
p_ni: 0.000008725
Score: 0.274
Data Source: BioPlex,STRINGDB
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.13346044
p_int: 0.999819087
p_ni: 0.000180913
Data Source: BioPlex
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.06135268
p_int: 0.998881251
p_ni: 0.001118749
Score: 0.16
Data Source: BioPlex,STRINGDB
VASN
Tbio
Novelty: 0.04337164
p_int: 0.997817037
p_ni: 0.002182963
Score: 0.18
Data Source: BioPlex,STRINGDB
XXYLT1
Tbio
Family: Enzyme
Novelty: 0.32851854
p_int: 0.979286285
p_ni: 0.020713715
Score: 0.292
Data Source: BioPlex,STRINGDB
ZFP41
Tdark
Family: TF
Novelty: 11
p_int: 0.975872517
p_ni: 0.024127483
Data Source: BioPlex
RBPJ
Tbio
Family: TF
Novelty: 0.00198074
p_int: 0.955686981
p_ni: 0.044313019
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
LRRIQ1
Tdark
p_int: 0.939366431
p_ni: 0.060633569
Score: 0.197
Data Source: BioPlex,STRINGDB
AGRP
Tbio
Novelty: 0.00207876
p_int: 0.877034491
p_ni: 0.122965509
Score: 0.228
Data Source: BioPlex,STRINGDB
MAML3
Tbio
Novelty: 0.0824416
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  345.35

PubMed score by year
PubTator Score  318.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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