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Tbio
RRAS2
Ras-related protein R-Ras2

Protein Summary
Description
It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256196
  • ENSP00000256196
  • ENSG00000133818
  • ENST00000414023
  • ENSP00000403282
  • ENST00000526063
  • ENSP00000434104
  • ENST00000529237
  • ENSP00000433230
  • ENST00000532814
  • ENSP00000431954
  • ENST00000534746
  • ENSP00000437083
  • ENST00000537760
  • ENSP00000437547

Symbol
  • TC21
  • TC21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.94
molecular function
0.91
interacting protein
0.9
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.78   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.78   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
6
6
9
10.8
99.9
seasonality measurement
1
1
0
10.8
44.2
1
1
0
1.1
2.2
high density lipoprotein cholesterol measurement
1
1
1
1.9
reticulocyte measurement
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
9
10.8
99.9
seasonality measurement
0
10.8
44.2
0
1.1
2.2
high density lipoprotein cholesterol measurement
1
1.9
reticulocyte measurement
1
1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (63)
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Autophagy - animal
KEGG
Regulation of actin cytoskeleton
KEGG
Mitophagy - animal
KEGG
C-type lectin receptor signaling pathway
KEGG
cAMP signaling pathway
Name
Explore in Pharos
Explore in Source
Autophagy - animal
Regulation of actin cytoskeleton
Mitophagy - animal
C-type lectin receptor signaling pathway
cAMP signaling pathway
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (158)
1 – 10 of 158
RIN1
Tbio
Novelty: 0.02401084
p_int: 0.97122315
p_ni: 0.02877685
Score: 0.91
Data Source: BioPlex,STRINGDB
RGL1
Tbio
Novelty: 0.0095933
p_int: 0.960530839
p_ni: 0.039469161
Score: 0.895
Data Source: BioPlex,STRINGDB
RAF1
Tclin
Family: Kinase
Novelty: 0.00117121
Score: 0.965
Data Source: STRINGDB
AFDN
Tbio
Novelty: 0.00372947
Score: 0.951
Data Source: STRINGDB
ARAF
Tchem
Family: Kinase
Novelty: 0.00432488
Score: 0.948
Data Source: STRINGDB
RALGDS
Tbio
Novelty: 0.00362484
Score: 0.944
Data Source: STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.943
Data Source: STRINGDB
PIK3CD
Tclin
Family: Kinase
Novelty: 0.00572779
Score: 0.937
Data Source: STRINGDB
SOS1
Tbio
Novelty: 0.00285343
Score: 0.933
Data Source: STRINGDB
NF1
Tbio
Novelty: 0.00019092
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.78

PubMed score by year
PubTator Score  32.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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