SBF2
Myotubularin-related protein 13
Protein Summary
Guanine nucleotide exchange factor (GEF) which may activate RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. This gene encodes a pseudophosphatase and member of the myotubularin-related protein family. This gene maps within the CMT4B2 candidate region of chromosome 11p15 and mutations in this gene have been associated with Charcot-Marie-Tooth Disease, type 4B2. [provided by RefSeq, Jul 2008]
- ENST00000256190
- ENSP00000256190
- ENSG00000133812
- CMT4B2
- KIAA1766
- MTMR13
- CMT4B2
- MTMR13
- DENND7B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
disease perturbation | 0.93 | ||
cell type or tissue | 0.86 | ||
trait | 0.86 | ||
molecular function | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.38 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 36 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.38 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 36 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0