Protein Classes
Protein Summary
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions ...more
- ENST00000255465
- ENSP00000255465
- ENSG00000133101
- ENST00000440264
- ENSP00000400666
- ENST00000625767
- ENSP00000486017
- ENST00000630422
- ENSP00000486482
- CT146
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.91 | ||
gene perturbation | 0.85 | ||
hub protein | 0.75 | ||
tissue sample | 0.74 | ||
histone modification site profile | 0.73 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 110.2 (req: < 5)
Gene RIFs: 52 (req: <= 3)
Antibodies: 408 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 110.2 (req: >= 5)
Gene RIFs: 52 (req: > 3)
Antibodies: 408 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (73)
Reactome (55)
KEGG (12)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 55
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | APC/C-mediated degradation of cell cycle proteins | ||||
Reactome | APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
Reactome | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | ||||
Reactome | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
Reactome | CDK-mediated phosphorylation and removal of Cdc6 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
APC/C-mediated degradation of cell cycle proteins | ||||
APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | ||||
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
CDK-mediated phosphorylation and removal of Cdc6 | ||||
Gene Ontology Terms (20)
Functions (2)
Components (7)
Processes (11)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (341)
1 – 10 of 341
CCNA2
Novelty: 0.00061948
p_int: 0.99999988
p_wrong: 1.2e-7
Score: 0.924
Data Source: BioPlex,STRINGDB
CDKN1A
Family: Enzyme
Novelty: 0.00038005
Score: 0.999
Data Source: STRINGDB
CDK1
Family: Kinase
Novelty: 0.00049984
Score: 0.995
Data Source: Reactome,STRINGDB
CDK2
Family: Kinase
Novelty: 0.00033882
Score: 0.994
Data Source: STRINGDB
CDC20
Novelty: 0.00237728
Score: 0.993
Data Source: STRINGDB
MCM6
Novelty: 0.0090985
Score: 0.993
Data Source: STRINGDB
MCM4
Novelty: 0.00884931
Score: 0.992
Data Source: STRINGDB
CDC6
Novelty: 0.00287878
Score: 0.985
Data Source: STRINGDB
CDC25A
Family: Enzyme
Novelty: 0.00322177
Score: 0.982
Data Source: STRINGDB
UBE2C
Novelty: 0.01031039
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score 110.20
PubMed score by year
PubTator Score 91.18
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVARGPDACQILT
1-70
RAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMD
70-140
ELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTE
140-210
YAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMS
210-280
VLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQ
280-350
YLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIV
350-420
PCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ
420-465
METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ
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