Tbio CCNA1 Cyclin-A1

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-a1

Protein Summary

Description

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P78396
• B7Z7E3
• Q5T3V0
• Q5U0G2
• Q8IY91

Gene Name

• CCNA1

Ensembl ID

• ENST00000255465
• ENSP00000255465
• ENSG00000133101
• ENST00000440264
• ENSP00000400666
• ENST00000625767
• ENSP00000486017
• ENST00000630422
• ENSP00000486482

Symbol

• CT146

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.91
gene perturbation	0.85
hub protein	0.75
tissue sample	0.74
histone modification site profile	0.73

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.2   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 408   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.2   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (73)

Reactome (55)

KEGG (12)

PathwayCommons (2)

WikiPathways (4)

APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

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Items per page:

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1 – 5 of 55

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
Reactome	APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409
Reactome	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	74 targets	R-HSA-179419
Reactome	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	77 targets	R-HSA-176814
Reactome	CDK-mediated phosphorylation and removal of Cdc6	73 targets	R-HSA-69017

Name	Explore in Pharos	Explore in Source
APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	74 targets	R-HSA-179419
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	77 targets	R-HSA-176814
CDK-mediated phosphorylation and removal of Cdc6	73 targets	R-HSA-69017

Gene Ontology Terms (20)

Functions (2)

Components (7)

Processes (11)

Items per page:

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1 – 2 of 2

GO Term	Evidence	Assigned by
cyclin-dependent protein serine/threonine kinase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein kinase binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (341)

Explore Interacting Targets

1 – 10 of 341

• See Interactions on String-DB

CCNA2

Tchem

Novelty: 0.00061948

p_int: 0.99999988

p_wrong: 1.2e-7

Score: 0.924

Data Source: BioPlex,STRINGDB

CDKN1A

Tbio

Family: Enzyme

Novelty: 0.00038005

Score: 0.999

Data Source: STRINGDB

CDK1

Tchem

Family: Kinase

Novelty: 0.00049984

Score: 0.995

Data Source: Reactome,STRINGDB

CDK2

Tchem

Family: Kinase

Novelty: 0.00033882

Score: 0.994

Data Source: STRINGDB

CDC20

Tbio

Novelty: 0.00237728

Score: 0.993

Data Source: STRINGDB

MCM6

Tbio

Novelty: 0.0090985

Score: 0.993

Data Source: STRINGDB

MCM4

Tbio

Novelty: 0.00884931

Score: 0.992

Data Source: STRINGDB

CDC6

Tbio

Novelty: 0.00287878

Score: 0.985

Data Source: STRINGDB

CDC25A

Tchem

Family: Enzyme

Novelty: 0.00322177

Score: 0.982

Data Source: STRINGDB

UBE2C

Tbio

Novelty: 0.01031039

Score: 0.979

Data Source: STRINGDB

Publication Statistics

PubMed Score  110.20

PubMed score by year

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PubTator Score  91.18

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVARGPDACQILT

1-70

RAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMD

70-140

ELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTE

140-210

YAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMS

210-280

VLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQ

280-350

YLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIV

350-420

PCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ

420-465

METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ

Find similar targets by:

Uniprot Keyword

Alternative splicing
Cell cycle
Cell division
Complete proteome
Cyclin
Mitosis
Nucleus
Reference proteome
Ubl conjugation