You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CHI3L1
Chitinase-3-like protein 1

Protein Summary
Description
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255409
  • ENSP00000255409
  • ENSG00000133048

Symbol
  • GP39
  • ASRT7
  • GP-39
  • YK-40
  • YKL40
  • CGP-39
  • YKL-40
  • YYL-40
  • HC-gp39
  • HCGP-3P
  • hCGP-39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
gene perturbation
0.96
biological process
0.91
protein domain
0.85
PubMedID
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1191.7   (req: < 5)
Gene RIFs: 525   (req: <= 3)
Antibodies: 406   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1191.7   (req: >= 5)
Gene RIFs: 525   (req: > 3)
Antibodies: 406   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0