Tbio CRP C-reactive protein

Protein Summary

Description

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P02741
• A8K078
• D3DVD9
• D3DVE0
• Q08AK3
• Q8WW75

Gene Name

• CRP

Ensembl ID

• ENST00000255030
• ENSP00000255030
• ENSG00000132693
• ENST00000368112
• ENSP00000357093

Symbol

• PTX1
• PTX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
chemical	0.99
molecular function	0.95
biological process	0.89
disease	0.81

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40016.37   (req: < 5)

Gene RIFs: 1888   (req: <= 3)

Antibodies: 1765   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40016.37   (req: >= 5)

Gene RIFs: 1888   (req: > 3)

Antibodies: 1765   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (7)

1 – 5 of 7

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (14)

Reactome (6)

PathwayCommons (2)

WikiPathways (6)

Classical antibody-mediated complement activation (R-HSA-173623)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Classical antibody-mediated complement activation	83 targets	R-HSA-173623
Reactome	Complement cascade	133 targets	R-HSA-166658
Reactome	Creation of C4 and C2 activators	91 targets	R-HSA-166786
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Initial triggering of complement	98 targets	R-HSA-166663

Name	Explore in Pharos	Explore in Source
Classical antibody-mediated complement activation	83 targets	R-HSA-173623
Complement cascade	133 targets	R-HSA-166658
Creation of C4 and C2 activators	91 targets	R-HSA-166786
Immune System	2246 targets	R-HSA-168256
Initial triggering of complement	98 targets	R-HSA-166663

Gene Ontology Terms (20)

Functions (6)

Components (2)

Processes (12)

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1 – 6 of 6

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	BHF-UCL
complement component C1q binding	Inferred from Direct Assay (IDA)	BHF-UCL
low-density lipoprotein particle binding	Inferred from Direct Assay (IDA)	BHF-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
low-density lipoprotein particle receptor binding	Inferred from Physical Interaction (IPI)	AgBase
choline binding	Traceable Author Statement (TAS)	BHF-UCL

Protein-Protein Interactions (407)

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1 – 10 of 407

• See Interactions on String-DB

CHST3

Tbio

Family: Enzyme

Novelty: 0.00504727

p_int: 0.99999996

p_ni: 3.8e-8

p_wrong: 1e-9

Score: 0.196

Data Source: BioPlex,STRINGDB

LAMA5

Tbio

Novelty: 0.02842048

p_int: 0.999999179

p_ni: 8.21e-7

Score: 0.157

Data Source: BioPlex,STRINGDB

PRSS23

Tbio

Family: Enzyme

Novelty: 0.22216345

p_int: 0.999998772

p_ni: 0.000001217

p_wrong: 1e-8

Data Source: BioPlex

CEMIP2

Tbio

Novelty: 0.0935128

p_int: 0.999991947

p_ni: 0.000008053

Data Source: BioPlex

AGRN

Tbio

Novelty: 0.0018427

p_int: 0.999966555

p_ni: 0.000033443

p_wrong: 2e-9

Score: 0.219

Data Source: BioPlex,STRINGDB

SPTB

Tbio

Novelty: 0.0031907

p_int: 0.999872012

p_ni: 0.000036675

p_wrong: 0.000091313

Score: 0.272

Data Source: BioPlex,STRINGDB

GDF11

Tclin

Novelty: 0.00702501

p_int: 0.999332903

p_ni: 0.000667051

p_wrong: 4.5e-8

Score: 0.185

Data Source: BioPlex,STRINGDB

C1GALT1

Tbio

Family: Enzyme

Novelty: 0.01514342

p_int: 0.999267601

p_ni: 0.00024213

p_wrong: 0.000490269

Score: 0.179

Data Source: BioPlex,STRINGDB

UBR3

Tbio

Family: Enzyme

Novelty: 0.11338583

p_int: 0.999129546

p_ni: 0.000870454

Data Source: BioPlex

QSOX1

Tbio

Family: Enzyme

Novelty: 0.02261166

p_int: 0.998767534

p_ni: 0.001232412

p_wrong: 5.4e-8

Data Source: BioPlex

Publication Statistics

PubMed Score  40016.37

PubMed score by year

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PubTator Score  37565.49

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acute phase
Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Disulfide bond
Metal-binding
Pyrrolidone carboxylic acid
Reference proteome

GWAS Trait Find Similar Targets

C-reactive protein measurement
glucose measurement
inflammatory biomarker measurement
inflammatory response
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mucocutaneous lymph node syndrome
triglyceride measurement

MGI Phenotype Find Similar Targets

homeostasis/metabolism phenotype
immune system phenotype