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Tbio
CRP
C-reactive protein

Protein Summary
Description
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255030
  • ENSP00000255030
  • ENSG00000132693
  • ENST00000368112
  • ENSP00000357093

Symbol
  • PTX1
  • PTX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
0.99
molecular function
0.95
biological process
0.89
disease
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40016.37   (req: < 5)
Gene RIFs: 1888   (req: <= 3)
Antibodies: 1765   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40016.37   (req: >= 5)
Gene RIFs: 1888   (req: > 3)
Antibodies: 1765   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Classical antibody-mediated complement activation (R-HSA-173623)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Classical antibody-mediated complement activation
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Classical antibody-mediated complement activation
Complement cascade
Creation of C4 and C2 activators
Immune System
Initial triggering of complement
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
AgBase
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (407)
1 – 10 of 407
CHST3
Tbio
Family: Enzyme
Novelty: 0.00504727
p_int: 0.99999996
p_ni: 3.8e-8
p_wrong: 1e-9
Score: 0.196
Data Source: BioPlex,STRINGDB
LAMA5
Tbio
Novelty: 0.02842048
p_int: 0.999999179
p_ni: 8.21e-7
Score: 0.157
Data Source: BioPlex,STRINGDB
PRSS23
Tbio
Family: Enzyme
Novelty: 0.22216345
p_int: 0.999998772
p_ni: 0.000001217
p_wrong: 1e-8
Data Source: BioPlex
CEMIP2
Tbio
Novelty: 0.0935128
p_int: 0.999991947
p_ni: 0.000008053
Data Source: BioPlex
AGRN
Tbio
Novelty: 0.0018427
p_int: 0.999966555
p_ni: 0.000033443
p_wrong: 2e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
SPTB
Tbio
Novelty: 0.0031907
p_int: 0.999872012
p_ni: 0.000036675
p_wrong: 0.000091313
Score: 0.272
Data Source: BioPlex,STRINGDB
GDF11
Tclin
Novelty: 0.00702501
p_int: 0.999332903
p_ni: 0.000667051
p_wrong: 4.5e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
C1GALT1
Tbio
Family: Enzyme
Novelty: 0.01514342
p_int: 0.999267601
p_ni: 0.00024213
p_wrong: 0.000490269
Score: 0.179
Data Source: BioPlex,STRINGDB
UBR3
Tbio
Family: Enzyme
Novelty: 0.11338583
p_int: 0.999129546
p_ni: 0.000870454
Data Source: BioPlex
QSOX1
Tbio
Family: Enzyme
Novelty: 0.02261166
p_int: 0.998767534
p_ni: 0.001232412
p_wrong: 5.4e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  40016.37

PubMed score by year
PubTator Score  37565.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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