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Tbio
SMARCC1
SWI/SNF complex subunit SMARCC1

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and different ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254480
  • ENSP00000254480
  • ENSG00000173473

Symbol
  • BAF155
  • Rsc8
  • SRG3
  • SWI3
  • BAF155
  • CRACC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
0.97
protein domain
0.97
disease perturbation
0.96
molecular function
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.73   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.73   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
69.3
smoking status measurement
1
1
1
56.1
household income
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
69.3
smoking status measurement
1
56.1
household income
1
15.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
VGNC:10473
460337
Mouse
MGI:1203524
20588
Rat
RGD:1304850
301020
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
VGNC:46535
476640
Horse
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
VGNC:23323
100064492
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Mouse
Rat
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Horse
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92922-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (231)
1 – 10 of 231
DPF3
Tbio
Family: Epigenetic
Novelty: 0.069151
p_int: 0.999847578
p_ni: 0.000152422
Score: 0.983
Data Source: BioPlex,STRINGDB
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.02625321
p_int: 0.999547974
p_ni: 0.000452026
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
SMARCB1
Tbio
Novelty: 0.00116387
p_int: 0.999420961
p_ni: 0.000579039
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SMARCD1
Tbio
Novelty: 0.03176642
p_int: 0.999194904
p_ni: 0.000805096
Score: 0.998
Data Source: BioPlex,STRINGDB
SS18
Tbio
Novelty: 0.00915548
p_int: 0.998251106
p_ni: 0.001748894
Score: 0.963
Data Source: BioPlex,STRINGDB
DPF2
Tbio
Family: Epigenetic
Novelty: 0.0403366
p_int: 0.998198758
p_ni: 0.001801242
Score: 0.95
Data Source: BioPlex,STRINGDB
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.997722542
p_ni: 0.002277458
Score: 0.898
Data Source: BioPlex,STRINGDB
SMARCE1
Tbio
Family: TF
Novelty: 0.01748089
p_int: 0.978968282
p_ni: 0.021031718
Score: 0.998
Data Source: BioPlex,STRINGDB
BCL7A
Tbio
Novelty: 0.07026394
p_int: 0.949505899
p_ni: 0.050494101
Score: 0.919
Data Source: BioPlex,STRINGDB
RABEP1
Tbio
Family: Enzyme
Novelty: 0.02318446
p_int: 0.946769125
p_ni: 0.053230875
Data Source: BioPlex
Publication Statistics
PubMed Score  97.73

PubMed score by year
PubTator Score  40.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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