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Tdark
WDR7
WD repeat-containing protein 7

Protein Summary
Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254442
  • ENSP00000254442
  • ENSG00000091157
  • ENST00000357574
  • ENSP00000350187

Symbol
  • KIAA0541
  • TRAG
  • TRAG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
histone modification site profile
0.84
disease perturbation
0.83
virus perturbation
0.79
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.76   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.76   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1
66.8
systolic blood pressure
1
1
1
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
66.8
systolic blood pressure
1
55.8
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (52)
1 – 10 of 52
ROGDI
Tbio
Novelty: 0.077277
p_int: 1
Score: 0.261
Data Source: BioPlex,STRINGDB
ATP6V1B1
Tchem
Family: Enzyme
Novelty: 0.01122589
p_int: 0.999996756
p_ni: 0.000003244
p_wrong: 1e-9
Score: 0.33
Data Source: BioPlex,STRINGDB
DMXL2
Tbio
Novelty: 0.06848356
Score: 0.9
Data Source: STRINGDB
RAB3GAP2
Tbio
Family: Enzyme
Novelty: 0.10321829
Score: 0.822
Data Source: STRINGDB
MADD
Tbio
Family: Enzyme
Novelty: 0.01590443
Score: 0.726
Data Source: STRINGDB
RAB3A
Tbio
Family: Enzyme
Novelty: 0.0043532
Score: 0.705
Data Source: STRINGDB
DNAJC5
Tbio
Novelty: 0.00091288
Score: 0.673
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.645
Data Source: STRINGDB
WDR53
Tdark
Novelty: 0.9750546
Score: 0.625
Data Source: STRINGDB
DNAJC5B
Tdark
Novelty: 0.28962584
Score: 0.622
Data Source: STRINGDB
Publication Statistics
PubMed Score  163.76

PubMed score by year
PubTator Score  19.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer