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Tbio
TRIM21
E3 ubiquitin-protein ligase TRIM21

Protein Summary
Description
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of I ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254436
  • ENSP00000254436
  • ENSG00000132109

Symbol
  • RNF81
  • RO52
  • SSA1
  • SSA
  • RO52
  • SSA1
  • RNF81
  • Ro/SSA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
protein complex
1
protein domain
1
virus perturbation
1


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1500.29   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 351   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1500.29   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 21
717826
Mouse
MGI:106657
20821
Rat
RGD:1305795
308901
Dog
tripartite motif containing 21
VGNC:47808
485226
Horse
tripartite motif containing 21
VGNC:24495
100066782
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 21
Mouse
Rat
Dog
tripartite motif containing 21
Horse
tripartite motif containing 21
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19474-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Reactome
Cytosolic sensors of pathogen-associated DNA
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (483)
1 – 10 of 483
TROVE2
Tbio
Novelty: 0.00306038
Score: 0.993
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.978
Data Source: STRINGDB
DDX41
Tbio
Family: Enzyme
Novelty: 0.01658581
Score: 0.97
Data Source: Reactome,STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.969
Data Source: STRINGDB
IRF8
Tbio
Family: TF
Novelty: 0.00330143
Score: 0.965
Data Source: STRINGDB
IRF5
Tbio
Family: TF
Novelty: 0.00341712
Score: 0.963
Data Source: STRINGDB
UBE2D2
Tbio
Novelty: 0.00603877
Score: 0.958
Data Source: STRINGDB
PML
Tbio
Novelty: 0.00285474
Score: 0.956
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.953
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  1500.29

PubMed score by year
PubTator Score  1017.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer