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Tdark
RSPH3
Radial spoke head protein 3 homolog

Protein Summary
Description
Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia. The protein encoded by this gene acts as a protein kinase A anchoring protein. Mutations in this gene cause primary ciliary dyskinesia; a disorder characterized by defects of the axoneme in motile cilia and sperm flagella. The homolog of this gene was first identified in the blue-green algae Chlamydomonas as encoding a radial spoke protein that formed a structural component of motile cilia and flagella. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252655
  • ENSP00000252655
  • ENSG00000130363

Symbol
  • RSHL2
  • RSP3
  • RSP3
  • RSHL2
  • CILD32
  • dJ111C20.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.78
virus perturbation
0.72
tissue sample
0.57
cell line
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.29   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.29   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (85)
1 – 10 of 85
RSPH6A
Tdark
Novelty: 0.03734897
Score: 0.866
Data Source: STRINGDB
MAATS1
Tbio
Novelty: 0.17802223
Score: 0.855
Data Source: STRINGDB
RSPH9
Tbio
Novelty: 0.08651313
Score: 0.841
Data Source: STRINGDB
RSPH1
Tbio
Novelty: 0.02982525
Score: 0.825
Data Source: STRINGDB
PCM1
Tbio
Novelty: 0.02901589
Score: 0.803
Data Source: STRINGDB
IPP
Tbio
Novelty: 0.12841634
Score: 0.802
Data Source: STRINGDB
ING3
Tbio
Family: Epigenetic
Novelty: 0.01696145
Score: 0.802
Data Source: STRINGDB
WTAP
Tbio
Novelty: 0.01491546
Score: 0.802
Data Source: STRINGDB
NANP
Tbio
Family: Enzyme
Novelty: 0.01876342
Score: 0.802
Data Source: STRINGDB
PPP1R21
Tdark
Family: Enzyme
Novelty: 0.33099657
Score: 0.802
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.29

PubMed score by year
PubTator Score  9.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer