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Tbio
GADD45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

Protein Summary
Description
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252506
  • ENSP00000252506
  • ENSG00000130222

Symbol
  • CR6
  • DDIT2
  • CR6
  • DDIT2
  • GRP17
  • GADD45gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.96
transcription factor binding site profile
0.96
virus perturbation
0.88
histone modification site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.87   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 732   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.87   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 732   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
46.1
self reported educational attainment
1
1
1
38.4
lifestyle measurement
1
1
1
24.7
1
1
1
10.5
intelligence
1
1
0
6
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
46.1
self reported educational attainment
1
38.4
lifestyle measurement
1
24.7
1
10.5
intelligence
0
6
2.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth arrest and DNA damage inducible gamma
VGNC:4748
464585
Mouse
MGI:1346325
23882
Rat
RGD:1311796
291005
Dog
growth arrest and DNA damage inducible gamma
VGNC:41071
484198
Horse
growth arrest and DNA damage inducible gamma
VGNC:18209
100054996
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth arrest and DNA damage inducible gamma
Mouse
Rat
Dog
growth arrest and DNA damage inducible gamma
Horse
growth arrest and DNA damage inducible gamma
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95257-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-small cell lung cancer
KEGG
Chronic myeloid leukemia
KEGG
Gastric cancer
KEGG
Melanoma
KEGG
Cell cycle
Name
Explore in Pharos
Explore in Source
Non-small cell lung cancer
Chronic myeloid leukemia
Gastric cancer
Melanoma
Cell cycle
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (36)
1 – 10 of 36
MAP3K4
Tbio
Family: Kinase
Novelty: 0.02186397
p_int: 0.999999964
p_ni: 3.6e-8
Score: 0.986
Data Source: BioPlex,STRINGDB
GADD45B
Tbio
Novelty: 0.00611526
Score: 0.949
Data Source: STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.942
Data Source: STRINGDB
GADD45A
Tbio
Novelty: 0.00178533
Score: 0.939
Data Source: STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.917
Data Source: STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
Score: 0.912
Data Source: STRINGDB
MAP2K3
Tchem
Family: Kinase
Novelty: 0.00349605
Score: 0.908
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.891
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.886
Data Source: STRINGDB
CCNB2
Tbio
Novelty: 0.00672914
Score: 0.856
Data Source: STRINGDB
Publication Statistics
PubMed Score  230.87

PubMed score by year
PubTator Score  34.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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