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Tbio
CNN1
Calponin-1

Protein Summary
Description
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252456
  • ENSP00000252456
  • ENSG00000130176

Symbol
  • SMCC
  • Sm-Calp
  • HEL-S-14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
gene perturbation
0.85
kinase perturbation
0.71
small molecule perturbation
0.67
hub protein
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.24   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 957   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.24   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 957   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
antiphospholipid antibody measurement
1
1
0
2.2
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
antiphospholipid antibody measurement
0
2.2
25.4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (35)
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Myometrial Relaxation and Contraction Pathways
WikiPathways
Myometrial Relaxation and Contraction Pathways
WikiPathways
Myometrial Relaxation and Contraction Pathways
WikiPathways
Ethanol metabolism resulting in production of ROS by CYP2E1
WikiPathways
Leptin signaling pathway
Name
Explore in Pharos
Explore in Source
Myometrial Relaxation and Contraction Pathways
Myometrial Relaxation and Contraction Pathways
Myometrial Relaxation and Contraction Pathways
Ethanol metabolism resulting in production of ROS by CYP2E1
Leptin signaling pathway
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (72)
1 – 10 of 72
MYEOV
Tbio
Novelty: 0.04142875
p_int: 0.846172384
p_ni: 0.153827616
Score: 0.685
Data Source: BioPlex,STRINGDB
RNF150
Tdark
Novelty: 0.49393737
p_int: 0.828216661
p_ni: 0.171783339
Score: 0.692
Data Source: BioPlex,STRINGDB
ACTG2
Tbio
Novelty: 0.00304944
Score: 0.907
Data Source: STRINGDB
MYH11
Tbio
Novelty: 0.00142474
Score: 0.893
Data Source: STRINGDB
ACTA2
Tbio
Novelty: 0.00199354
Score: 0.798
Data Source: STRINGDB
SMTN
Tbio
Novelty: 0.00653788
Score: 0.752
Data Source: STRINGDB
SPEF1
Tdark
Novelty: 0.14564815
Score: 0.748
Data Source: STRINGDB
ACTA1
Tbio
Novelty: 0.00111813
Score: 0.736
Data Source: STRINGDB
NAV2
Tbio
Novelty: 0.0186325
Score: 0.71
Data Source: STRINGDB
MYOCD
Tbio
Novelty: 0.00354211
Score: 0.694
Data Source: STRINGDB
Publication Statistics
PubMed Score  116.24

PubMed score by year
PubTator Score  37.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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