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Tbio
ESS2
Splicing factor ESS-2 homolog

Protein Summary
Description
May be involved in pre-mRNA splicing. This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252137
  • ENSP00000252137
  • ENSG00000100056

Symbol
  • DGCR13
  • DGCR14
  • DGSH
  • DGSI
  • ES2
  • ES2
  • DGSH
  • DGSI
  • bis1
  • DGS-H
  • DGS-I
  • ESS-2
  • Es2el
  • DGCR13
  • DGCR14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.6   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.6   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (78)
1 – 10 of 78
HINT3
Tdark
Novelty: 1.14285714
p_int: 0.99988837
p_ni: 0.00011163
Data Source: BioPlex
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.999788272
p_ni: 0.000211714
p_wrong: 1.4e-8
Data Source: BioPlex
S100A4
Tbio
Novelty: 0.00136919
p_int: 0.999476829
p_ni: 0.00052315
p_wrong: 2.1e-8
Data Source: BioPlex
BCAS2
Tbio
Novelty: 0.05425016
p_int: 0.999437591
p_ni: 0.000562409
Data Source: BioPlex
FAM170A
Tdark
Novelty: 0.05778712
p_int: 0.999410785
p_ni: 0.000589215
Data Source: BioPlex
FRA10AC1
Tdark
Novelty: 0.25570773
p_int: 0.998623885
p_ni: 0.001374666
p_wrong: 0.000001448
Score: 0.828
Data Source: BioPlex,STRINGDB
PRPF19
Tbio
Novelty: 0.01616737
p_int: 0.996906487
p_ni: 0.003093513
Score: 0.892
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.996729873
p_ni: 0.003270124
p_wrong: 3e-9
Data Source: BioPlex
SNRPA1
Tbio
Novelty: 0.01232044
p_int: 0.99633328
p_ni: 0.003666718
p_wrong: 3e-9
Score: 0.216
Data Source: BioPlex,STRINGDB
SNW1
Tbio
Novelty: 0.01423797
p_int: 0.996081389
p_ni: 0.003918611
Score: 0.466
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  558.60

PubMed score by year
PubTator Score  147.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer