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Tdark
DHX35
Probable ATP-dependent RNA helicase DHX35

Protein Summary
Description
May be involved in pre-mRNA splicing. DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252011
  • ENSP00000252011
  • ENSG00000101452
  • ENST00000373323
  • ENSP00000362420

Symbol
  • C20orf15
  • DDX35
  • DDX35
  • C20orf15
  • KAIA0875
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor binding site profile
0.95
kinase perturbation
0.93
histone modification site profile
0.92
virus perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.72   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.72   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
86.8
1
1
0
1.1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
86.8
0
1.1
0.5
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (168)
1 – 10 of 168
WDR83
Tbio
Novelty: 0.11602568
p_int: 0.999998324
p_ni: 0.000001676
Score: 0.584
Data Source: BioPlex,STRINGDB
USB1
Tbio
Family: Enzyme
Novelty: 0.01677996
p_int: 0.999991395
p_ni: 0.000008601
p_wrong: 5e-9
Score: 0.741
Data Source: BioPlex,STRINGDB
BCAS2
Tbio
Novelty: 0.05425016
p_int: 0.999982729
p_ni: 0.000017271
Score: 0.396
Data Source: BioPlex,STRINGDB
PRPF19
Tbio
Novelty: 0.01616737
p_int: 0.999940177
p_ni: 0.000059823
Score: 0.922
Data Source: BioPlex,STRINGDB
SYF2
Tbio
Novelty: 0.06114903
p_int: 0.999935841
p_ni: 0.000064159
Score: 0.803
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.999928005
p_ni: 0.000071995
Score: 0.833
Data Source: BioPlex,STRINGDB
TSSC4
Tdark
Novelty: 0.17064786
p_int: 0.999887707
p_ni: 0.000112293
Score: 0.663
Data Source: BioPlex,STRINGDB
SNRPGP15
Tdark
p_int: 0.999857195
p_ni: 0.000142804
Data Source: BioPlex
SNW1
Tbio
Novelty: 0.01423797
p_int: 0.999661485
p_ni: 0.000338515
Score: 0.866
Data Source: BioPlex,STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
p_int: 0.99936587
p_ni: 0.000634124
p_wrong: 7e-9
Score: 0.793
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.72

PubMed score by year
PubTator Score  0.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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