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Tclin
RAF1
RAF proto-oncogene serine/threonine-protein kinase

Protein Summary
Description
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in moti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251849
  • ENSP00000251849
  • ENSG00000132155
  • ENST00000442415
  • ENSP00000401888

Symbol
  • RAF
  • NS5
  • CRAF
  • Raf-1
  • c-Raf
  • CMD1NN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease perturbation
1
hub protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.61   (req: < 5)
Gene RIFs: 237   (req: <= 3)
Antibodies: 2878   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.61   (req: >= 5)
Gene RIFs: 237   (req: > 3)
Antibodies: 2878   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 383
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
sorafenib
chemical structure image
encorafenib
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
67.7
electrocardiography
1
1
3
30.4
total cholesterol measurement
1
1
1
28.4
1
1
0
1
23.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
67.7
electrocardiography
3
30.4
total cholesterol measurement
1
28.4
0
1
23.4
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (274)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Cytokine Signaling in Immune system
Disease
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (322)
1 – 10 of 322
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
p_int: 0.999973271
p_ni: 0.000026729
Score: 0.952
Data Source: BioPlex,Reactome,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.999
Data Source: Reactome,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.998
Data Source: Reactome,STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
Score: 0.998
Data Source: Reactome,STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.996
Data Source: Reactome,STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.995
Data Source: Reactome,STRINGDB
MAP2K1
Tclin
Family: Kinase
Novelty: 0.0005278
Score: 0.989
Data Source: Reactome,STRINGDB
YWHAB
Tchem
Novelty: 0.00614093
Score: 0.988
Data Source: Reactome,STRINGDB
YWHAE
Tbio
Novelty: 0.00431876
Score: 0.988
Data Source: STRINGDB
MAP2K2
Tclin
Family: Kinase
Novelty: 0.00706525
Score: 0.988
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  731.61

PubMed score by year
PubTator Score  1441.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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