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Tbio
GRHL2
Grainyhead-like protein 2 homolog

Protein Summary
Description
Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in dif ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251808
  • ENSP00000251808
  • ENSG00000083307
  • ENST00000395927
  • ENSP00000379260
  • ENST00000646743
  • ENSP00000495564

Symbol
  • BOM
  • TFCP2L3
  • BOM
  • ECTDS
  • PPCD4
  • DFNA28
  • TFCP2L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
virus perturbation
0.83
PubMedID
0.76
kinase perturbation
0.71
molecular function
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.26   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.26   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Integrin-mediated Cell Adhesion
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
Name
Explore in Pharos
Explore in Source
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Integrin-mediated Cell Adhesion
Endoderm Differentiation
Endoderm Differentiation
Gene Ontology Terms (34)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (39)
1 – 10 of 39
GRHL1
Tbio
Family: TF
Novelty: 0.02132567
p_int: 0.999999644
p_ni: 2.52e-7
p_wrong: 1.04e-7
Score: 0.714
Data Source: BioPlex,STRINGDB
ESRP1
Tbio
Novelty: 0.02035464
Score: 0.855
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.794
Data Source: STRINGDB
ZEB1
Tbio
Family: TF
Novelty: 0.00085257
Score: 0.76
Data Source: STRINGDB
MMACHC
Tbio
Novelty: 0.00896291
Score: 0.756
Data Source: STRINGDB
EPCAM
Tbio
Novelty: 0.00042422
Score: 0.733
Data Source: STRINGDB
OVOL2
Tbio
Family: TF
Novelty: 0.05018827
Score: 0.719
Data Source: STRINGDB
GTF2H5
Tbio
Novelty: 0.03493285
Score: 0.705
Data Source: STRINGDB
RAB25
Tbio
Family: Enzyme
Novelty: 0.01889483
Score: 0.69
Data Source: STRINGDB
ZNF687
Tbio
Family: TF
Novelty: 0.14707532
Score: 0.672
Data Source: STRINGDB
Publication Statistics
PubMed Score  118.26

PubMed score by year
PubTator Score  51.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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