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Tbio
KRT12
Keratin, type I cytoskeletal 12

Protein Summary
Description
May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity). KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251643
  • ENSP00000251643
  • ENSG00000187242
  • ENST00000572470
  • ENSP00000459559
  • ENSG00000263243
  • ENST00000647992
  • ENSP00000497200

Symbol
  • K12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
cellular component
0.6
gene perturbation
0.58
virus perturbation
0.55
cell line
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.81   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.81   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
keratin 12
702476
Mouse
MGI:96687
268482
Rat
RGD:1304805
360625
Dog
keratin 12
VGNC:42517
100034663
Horse
keratin 12
VGNC:19521
100067513
Species
Name
OMA
EggNOG
Inparanoid
Macaque
keratin 12
Mouse
Rat
Dog
keratin 12
Horse
keratin 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99456-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
ProtInc
Protein-Protein Interactions (82)
1 – 10 of 82
KRT1
Tbio
Novelty: 0.00278467
Score: 0.944
Data Source: STRINGDB
KRT3
Tbio
Novelty: 0.00489796
Score: 0.935
Data Source: STRINGDB
KRT4
Tbio
Novelty: 0.00434637
Score: 0.928
Data Source: STRINGDB
KRT82
Tdark
Novelty: 0.5488139
Score: 0.925
Data Source: STRINGDB
KRT77
Tbio
Novelty: 0.01331186
Score: 0.925
Data Source: STRINGDB
KRT73
Tdark
Novelty: 0.36334003
Score: 0.924
Data Source: STRINGDB
KRT72
Tbio
Novelty: 0.06391566
Score: 0.924
Data Source: STRINGDB
KRT76
Tdark
Novelty: 0.87892674
Score: 0.924
Data Source: STRINGDB
KRT5
Tbio
Novelty: 0.00072336
Score: 0.924
Data Source: STRINGDB
KRT81
Tbio
Novelty: 0.05514238
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  67.81

PubMed score by year
PubTator Score  201.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer