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Tbio
DHX58
Probable ATP-dependent RNA helicase DHX58

Protein Summary
Description
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immun ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251642
  • ENSP00000251642
  • ENSG00000108771

Symbol
  • D11LGP2E
  • LGP2
  • LGP2
  • RLR-3
  • D11LGP2
  • D11lgp2e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.99
protein domain
0.73
biological process
0.64
cell type or tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.68   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.68   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (136)
1 – 10 of 136
DDX58
Tbio
Family: Enzyme
Novelty: 0.00108351
Score: 0.964
Data Source: STRINGDB
IFIH1
Tbio
Family: Enzyme
Novelty: 0.00169761
Score: 0.929
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00256125
Score: 0.918
Data Source: STRINGDB
RSAD2
Tbio
Novelty: 0.00786985
Score: 0.913
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.00308898
Score: 0.908
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00081841
Score: 0.866
Data Source: STRINGDB
MAVS
Tbio
Novelty: 0.00214049
Score: 0.865
Data Source: STRINGDB
DICER1
Tbio
Family: Enzyme
Novelty: 0.00042715
Score: 0.845
Data Source: STRINGDB
USP18
Tbio
Family: Enzyme
Novelty: 0.01398634
Score: 0.844
Data Source: STRINGDB
OASL
Tbio
Family: Enzyme
Novelty: 0.02020019
Score: 0.835
Data Source: STRINGDB
Publication Statistics
PubMed Score  49.68

PubMed score by year
PubTator Score  69.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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