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Tchem
MAST1
Microtubule-associated serine/threonine-protein kinase 1

Protein Classes
Protein Summary
Description
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251472
  • ENSP00000251472
  • ENSG00000105613

Symbol
  • KIAA0973
  • SAST
  • SAST
  • MCCCHCM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.95
virus perturbation
0.72
tissue sample
0.71
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.54   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.54   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL603469
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (61)
1 – 10 of 61
PTEN
Tchem
Family: Enzyme
Novelty: 0.00017995
Score: 0.784
Data Source: STRINGDB
MAGI2
Tbio
Family: Enzyme
Novelty: 0.02248802
Score: 0.74
Data Source: STRINGDB
S100B
Tchem
Novelty: 0.00038202
Score: 0.723
Data Source: STRINGDB
FRYL
Tdark
Novelty: 0.13475936
Score: 0.63
Data Source: STRINGDB
FRY
Tdark
Novelty: 0.00065636
Score: 0.63
Data Source: STRINGDB
JADE2
Tbio
Family: Epigenetic
Novelty: 0.47295209
Score: 0.595
Data Source: STRINGDB
PLK5
Tbio
Family: Kinase
Novelty: 0.24566192
Score: 0.586
Data Source: STRINGDB
PPP2R2C
Tbio
Family: Enzyme
Novelty: 0.06762579
Score: 0.584
Data Source: STRINGDB
PPP2R2B
Tbio
Family: Enzyme
Novelty: 0.0161608
Score: 0.582
Data Source: STRINGDB
ELAVL4
Tbio
Novelty: 0.00276378
Score: 0.579
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.54

PubMed score by year
PubTator Score  18.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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