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Tbio
DOCK7
Dedicator of cytokinesis protein 7

Protein Summary
Description
Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251157
  • ENSP00000251157
  • ENSG00000116641
  • ENST00000340370
  • ENSP00000340742
  • ENST00000404627
  • ENSP00000384446
  • ENST00000454575
  • ENSP00000413583
  • ENST00000634264
  • ENSP00000489284
  • ENST00000635123
  • ENSP00000489499
  • ENST00000635253
  • ENSP00000489124

Symbol
  • KIAA1771
  • ZIR2
  • EIEE23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
trait
0.93
histone modification site profile
0.81
protein domain
0.73
cell line
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.3   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.3   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
21
19
52
4.9
99.7
total cholesterol measurement
12
18
31
2.8
99.4
vitamin D measurement
2
2
2
98.4
low density lipoprotein cholesterol measurement
8
13
22
2
98.2
lipid measurement
2
2
2
86.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
52
4.9
99.7
total cholesterol measurement
31
2.8
99.4
vitamin D measurement
2
98.4
low density lipoprotein cholesterol measurement
22
2
98.2
lipid measurement
2
86.8
Pathways (9)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
MET activates RAP1 and RAC1
Reactome
MET promotes cell motility
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
MET activates RAP1 and RAC1
MET promotes cell motility
Signal Transduction
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
LRCH1
Tbio
Novelty: 0.0923291
p_int: 0.999999657
p_ni: 3.43e-7
Score: 0.525
Data Source: BioPlex,STRINGDB
LRCH3
Tdark
Novelty: 1.02650989
p_int: 0.999999533
p_ni: 4.67e-7
Score: 0.785
Data Source: BioPlex,STRINGDB
DOCK8
Tbio
Novelty: 0.0067047
p_int: 0.999963249
p_ni: 0.000036751
Score: 0.704
Data Source: BioPlex,STRINGDB
MOB1B
Tbio
Family: Enzyme
Novelty: 0.0718959
p_int: 0.999698368
p_ni: 0.000301632
Score: 0.343
Data Source: BioPlex,STRINGDB
ARPC3
Tbio
Novelty: 0.02951522
p_int: 0.999460304
p_ni: 0.000539696
Score: 0.546
Data Source: BioPlex,STRINGDB
PIH1D1
Tbio
Novelty: 0.10737369
p_int: 0.997231156
p_ni: 0.002768844
Data Source: BioPlex
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
p_int: 0.993589848
p_ni: 0.006410152
Data Source: BioPlex
AVIL
Tbio
Novelty: 0.0175973
p_int: 0.99117639
p_ni: 0.00882361
Score: 0.168
Data Source: BioPlex,STRINGDB
TMOD3
Tbio
Novelty: 0.04744699
p_int: 0.97454735
p_ni: 0.02545265
Data Source: BioPlex
ZNF785
Tdark
Family: TF
Novelty: 0.42629766
p_int: 0.945547955
p_ni: 0.054452045
Data Source: BioPlex
Publication Statistics
PubMed Score  30.30

PubMed score by year
PubTator Score  10.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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