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Tbio
LMAN1
Protein ERGIC-53

Protein Summary
Description
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
histone modification site profile
0.77
virus perturbation
0.76
cellular component
0.75
small molecule perturbation
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.71   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.71   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cardiac troponin I measurement
1
1
1
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cardiac troponin I measurement
1
62.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lectin, mannose binding 1
VGNC:10016
455448
Macaque
lectin, mannose binding 1
697449
Mouse
MGI:1917611
70361
Rat
RGD:71020
116666
Dog
lectin, mannose binding 1
VGNC:42706
476186
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lectin, mannose binding 1
Macaque
lectin, mannose binding 1
Mouse
Rat
Dog
lectin, mannose binding 1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49257-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Membrane Trafficking
Gene Ontology Terms (25)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (158)
1 – 10 of 158
GINM1
Tdark
Novelty: 1.0701107
p_int: 0.84043376
p_ni: 0.15956624
Score: 0.221
Data Source: BioPlex,STRINGDB
MCFD2
Tbio
Novelty: 0.0402944
Score: 0.999
Data Source: Reactome,STRINGDB
SEC31A
Tbio
Novelty: 0.0350228
Score: 0.979
Data Source: STRINGDB
SEC24C
Tbio
Novelty: 0.05842956
Score: 0.978
Data Source: STRINGDB
F8
Tbio
Novelty: 0.0002287
Score: 0.976
Data Source: Reactome,STRINGDB
SEC13
Tbio
Novelty: 0.00709413
Score: 0.976
Data Source: STRINGDB
STX5
Tbio
Novelty: 0.00964918
Score: 0.976
Data Source: STRINGDB
SEC23A
Tbio
Novelty: 0.0384262
Score: 0.975
Data Source: STRINGDB
SEC22B
Tbio
Novelty: 0.03035448
Score: 0.974
Data Source: STRINGDB
SEC16A
Tbio
Novelty: 0.02221416
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  167.71

PubMed score by year
PubTator Score  141.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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