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Tclin
TPH1
Tryptophan 5-hydroxylase 1

Protein Summary
Description
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250018
  • ENSP00000250018
  • ENSG00000129167

Symbol
  • TPH
  • TPRH
  • TRPH
  • TPRH
  • TRPH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease
0.72
gene perturbation
0.67
molecular function
0.63
biological process
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 938.86   (req: < 5)
Gene RIFs: 129   (req: <= 3)
Antibodies: 545   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 938.86   (req: >= 5)
Gene RIFs: 129   (req: > 3)
Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 118
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
telotristat ethyl
chemical structure image
Active Ligands (118)
1 – 10 of 118
CHEMBL471564
chemical structure image
CHEMBL479924
chemical structure image
CHEMBL471380
chemical structure image
CHEMBL576031,CHEMBL567037
chemical structure image
CHEMBL459856,CHEMBL518324
chemical structure image
CHEMBL3799607,CHEMBL3799306
chemical structure image
CHEMBL470084
chemical structure image
CHEMBL460882
chemical structure image
CHEMBL2103855
chemical structure image
CHEMBL511960
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
13.5
myeloid white cell count
1
1
1
11.2
high density lipoprotein cholesterol measurement
1
1
1
1.6
leukocyte count
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
13.5
myeloid white cell count
1
11.2
high density lipoprotein cholesterol measurement
1
1.6
leukocyte count
1
0.2
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Reactome
Serotonin and melatonin biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Serotonin and melatonin biosynthesis
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (128)
1 – 10 of 128
TPH2
Tchem
Family: Enzyme
Novelty: 0.00265377
p_int: 0.999999956
p_ni: 1e-9
p_wrong: 4.3e-8
Score: 0.814
Data Source: BioPlex,STRINGDB
DNAJC12
Tbio
Novelty: 0.05214775
p_int: 0.999988505
p_ni: 0.000011495
Score: 0.324
Data Source: BioPlex,STRINGDB
MCM10
Tbio
Novelty: 0.0136058
p_int: 0.999733412
p_ni: 0.000266588
Score: 0.254
Data Source: BioPlex,STRINGDB
YEATS4
Tbio
Novelty: 0.02632024
p_int: 0.993974288
p_ni: 0.006025712
Score: 0.179
Data Source: BioPlex,STRINGDB
RFWD3
Tbio
Family: Enzyme
Novelty: 0.0859205
p_int: 0.973409898
p_ni: 0.019901478
p_wrong: 0.006688624
Score: 0.206
Data Source: BioPlex,STRINGDB
DDC
Tclin
Family: Enzyme
Novelty: 0.0012284
Score: 0.985
Data Source: STRINGDB
QDPR
Tchem
Family: Enzyme
Novelty: 0.00836889
Score: 0.974
Data Source: STRINGDB
SPR
Tchem
Family: Enzyme
Novelty: 0.02144934
Score: 0.965
Data Source: STRINGDB
TDO2
Tchem
Family: Enzyme
Novelty: 0.00115832
Score: 0.965
Data Source: STRINGDB
PCBD1
Tbio
Family: Enzyme
Novelty: 0.01564376
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  938.86

PubMed score by year
PubTator Score  191.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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