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Tbio
MYOD1
Myoblast determination protein 1

Protein Summary
Description
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250003
  • ENSP00000250003
  • ENSG00000129152

Symbol
  • BHLHC1
  • MYF3
  • MYOD
  • PUM
  • MYF3
  • MYOD
  • bHLHc1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
hub protein
0.99
molecular function
0.99
gene perturbation
0.98
kinase
0.8


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1800.86   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 976   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1800.86   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 976   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myogenic differentiation 1
VGNC:3100
451057
Macaque
myogenic differentiation 1
696222
Mouse
MGI:97275
17927
Rat
RGD:631429
337868
Dog
myogenic differentiation 1
VGNC:43578
611940
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myogenic differentiation 1
Macaque
myogenic differentiation 1
Mouse
Rat
Dog
myogenic differentiation 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P15172-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Myogenesis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Myogenesis
Gene Ontology Terms (49)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (358)
1 – 10 of 358
TCF3
Tbio
Family: TF
Novelty: 0.00112675
Score: 0.991
Data Source: Reactome,STRINGDB
MEF2C
Tbio
Family: TF
Novelty: 0.00232724
Score: 0.987
Data Source: Reactome,STRINGDB
MEF2A
Tbio
Family: TF
Novelty: 0.00439393
Score: 0.987
Data Source: Reactome,STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.982
Data Source: STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.0019718
Score: 0.979
Data Source: STRINGDB
MEF2D
Tbio
Family: TF
Novelty: 0.00732653
Score: 0.978
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.973
Data Source: STRINGDB
TCF12
Tbio
Family: TF
Novelty: 0.00381424
Score: 0.972
Data Source: STRINGDB
HEY1
Tbio
Family: TF
Novelty: 0.0042366
Score: 0.968
Data Source: STRINGDB
PAX7
Tbio
Family: TF
Novelty: 0.00142843
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  1800.86

PubMed score by year
PubTator Score  756.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer