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Tbio
COPB1
Coatomer subunit beta

Protein Summary
Description
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249923
  • ENSP00000249923
  • ENSG00000129083
  • ENST00000439561
  • ENSP00000397873

Symbol
  • COPB
  • COPB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
virus perturbation
0.98
kinase perturbation
0.88
histone modification site profile
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.83   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.83   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
3
3
99.8
2
1
2
83.3
body height
1
1
1
65.3
low density lipoprotein cholesterol measurement
1
1
1
58.5
high density lipoprotein cholesterol measurement
1
1
1
31.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
99.8
2
83.3
body height
1
65.3
low density lipoprotein cholesterol measurement
1
58.5
high density lipoprotein cholesterol measurement
1
31.8
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (364)
1 – 10 of 364
COPG1
Tbio
Novelty: 0.01331193
p_int: 0.99988785
p_ni: 0.00011215
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
COPZ1
Tbio
Novelty: 0.01405958
p_int: 0.999056502
p_ni: 0.000943498
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
COPZ2
Tdark
Novelty: 0.21561497
p_int: 0.961327447
p_ni: 0.038672553
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
SEC61B
Tbio
Novelty: 0.08622222
p_int: 0.952425224
p_ni: 0.047574776
Score: 0.163
Data Source: BioPlex,STRINGDB
COPG2
Tbio
Novelty: 0.06126837
Score: 0.999
Data Source: Reactome,STRINGDB
COPA
Tbio
Novelty: 0.02712824
Score: 0.999
Data Source: Reactome,STRINGDB
COPB2
Tbio
Novelty: 0.02705751
Score: 0.999
Data Source: Reactome,STRINGDB
COPE
Tbio
Novelty: 0.02037359
Score: 0.999
Data Source: Reactome,STRINGDB
ARCN1
Tbio
Novelty: 0.06716916
Score: 0.999
Data Source: Reactome,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  128.83

PubMed score by year
PubTator Score  31.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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