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Tbio
STYXL1
Serine/threonine/tyrosine-interacting-like protein 1

Protein Summary
Description
Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248600
  • ENSP00000248600
  • ENSG00000127952
  • ENST00000340062
  • ENSP00000343383
  • ENST00000359697
  • ENSP00000352726
  • ENST00000360591
  • ENSP00000353798
  • ENST00000431581
  • ENSP00000392221

Symbol
  • DUSP24
  • MKSTYX
  • DUSP24
  • MKSTYX
  • MK-STYX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
cell type or tissue
0.78
protein domain
0.73
virus perturbation
0.72
cellular component
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.02   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.02   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
49.3
myeloid white cell count
1
1
1
45.1
mean platelet volume
1
1
1
32.6
eosinophil count
1
1
1
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
49.3
myeloid white cell count
1
45.1
mean platelet volume
1
32.6
eosinophil count
1
26.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1923821
76571
Rat
RGD:1305845
360792
Horse
serine/threonine/tyrosine interacting like 1
VGNC:23740
100061080
Cow
serine/threonine/tyrosine interacting like 1
VGNC:35453
513107
Opossum
serine/threonine/tyrosine interacting like 1
100029169
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
serine/threonine/tyrosine interacting like 1
Cow
serine/threonine/tyrosine interacting like 1
Opossum
serine/threonine/tyrosine interacting like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6J8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (25)
1 – 10 of 25
G3BP1
Tbio
Family: Enzyme
Novelty: 0.00589987
Score: 0.689
Data Source: STRINGDB
PTPMT1
Tbio
Family: Enzyme
Novelty: 0.04547035
Score: 0.672
Data Source: STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.592
Data Source: STRINGDB
EXOSC8
Tbio
Family: Enzyme
Novelty: 0.02013403
Score: 0.575
Data Source: STRINGDB
EFCAB11
Tdark
Novelty: 0.68998855
Score: 0.546
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.533
Data Source: STRINGDB
LCMT1
Tbio
Family: Enzyme
Novelty: 0.03504409
Score: 0.519
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.507
Data Source: STRINGDB
PTPN7
Tchem
Family: Enzyme
Novelty: 0.02742398
Score: 0.504
Data Source: STRINGDB
ENPP6
Tbio
Family: Enzyme
Novelty: 0.06933544
Score: 0.494
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.02

PubMed score by year
PubTator Score  6.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer