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Tbio
KRT13
Keratin, type I cytoskeletal 13

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246635
  • ENSP00000246635
  • ENSG00000171401
  • ENST00000336861
  • ENSP00000336604

Symbol
  • K13
  • CK13
  • WSN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
ligand (protein) perturbation
0.96
PubMedID
0.94
gene perturbation
0.92
small molecule perturbation
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.13   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 530   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.13   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 530   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 13
VGNC:9435
100610505
Mouse
MGI:101925
16663
Rat
RGD:1302937
287699
Dog
keratin 13
490983
Pig
keratin, type I cytoskeletal 13
100515166
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 13
Mouse
Rat
Dog
keratin 13
Pig
keratin, type I cytoskeletal 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P13646-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (65)
1 – 10 of 65
KRT4
Tbio
Novelty: 0.00434637
Score: 0.961
Data Source: STRINGDB
KRT15
Tbio
Novelty: 0.00351898
Score: 0.952
Data Source: STRINGDB
KRT7
Tbio
Novelty: 0.00039796
Score: 0.949
Data Source: STRINGDB
KRT6A
Tbio
Novelty: 0.00789111
Score: 0.947
Data Source: STRINGDB
KRT1
Tbio
Novelty: 0.00278467
Score: 0.946
Data Source: STRINGDB
KRT8
Tbio
Novelty: 0.00093008
Score: 0.941
Data Source: STRINGDB
KRT5
Tbio
Novelty: 0.00072336
Score: 0.94
Data Source: STRINGDB
KRT6C
Tbio
Novelty: 0.11659743
Score: 0.933
Data Source: STRINGDB
KRT6B
Tbio
Novelty: 0.00152754
Score: 0.931
Data Source: STRINGDB
KRT3
Tbio
Novelty: 0.00489796
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  204.13

PubMed score by year
PubTator Score  298.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer