Protein Summary
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000246069
- ENSP00000246069
- ENSG00000125868
- ENST00000474024
- ENSP00000476975
- ACTDP
- DSN
- ADF
- ACTDP
- HEL32
- bA462D18.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
virus perturbation | 1 | ||
transcription factor perturbation | 0.94 | ||
transcription factor binding site profile | 0.89 | ||
kinase perturbation | 0.84 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.21 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 349 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.21 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 349 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (118)
WikiPathways (118)
Items per page:
1 – 5 of 118
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Androgen receptor signaling pathway | ||||
WikiPathways | Androgen receptor signaling pathway | ||||
WikiPathways | Androgen receptor signaling pathway | ||||
WikiPathways | Androgen receptor signaling pathway | ||||
WikiPathways | Androgen receptor signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Androgen receptor signaling pathway | ||||
Androgen receptor signaling pathway | ||||
Androgen receptor signaling pathway | ||||
Androgen receptor signaling pathway | ||||
Androgen receptor signaling pathway | ||||
Gene Ontology Terms (9)
Functions (1)
Components (3)
Processes (5)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (159)
1 – 10 of 159
ACTB
Novelty: 0.00027728
Score: 0.912
Data Source: STRINGDB
ACTG1
Novelty: 0.00111542
Score: 0.905
Data Source: STRINGDB
WDR1
Novelty: 0.02141132
Score: 0.872
Data Source: STRINGDB
TWF1
Novelty: 0.06393105
Score: 0.846
Data Source: STRINGDB
RPS6
Novelty: 0.00155552
Score: 0.831
Data Source: STRINGDB
RBM24
Novelty: 0.05713269
Score: 0.827
Data Source: STRINGDB
LIMK1
Family: Kinase
Novelty: 0.0046681
Score: 0.8
Data Source: STRINGDB
TPM4
Novelty: 0.00688369
Score: 0.794
Data Source: STRINGDB
SSH1
Family: Enzyme
Novelty: 0.02721177
Score: 0.777
Data Source: STRINGDB
LIMK2
Family: Kinase
Novelty: 0.0180473
Score: 0.772
Data Source: STRINGDB
Publication Statistics
PubMed Score 62.21
PubMed score by year
PubTator Score 304.08
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKH
1-70
FVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGP
70-140
EDLNRACIAEKLGGSLIVAFEGCPV
140-165
MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
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