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Tdark
TMX4
Thioredoxin-related transmembrane protein 4

Protein Summary
Description
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246024
  • ENSP00000246024
  • ENSG00000125827

Symbol
  • KIAA1162
  • TXNDC13
  • PDIA14
  • TXNDC13
  • DJ971N18.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.96
histone modification site profile
0.85
transcription factor binding site profile
0.78
microRNA
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.46   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.46   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
1
10.4
sleep duration
1
1
1
10.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
10.4
sleep duration
1
10.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
thioredoxin related transmembrane protein 4
718375
Mouse
MGI:106558
52837
Rat
RGD:1305146
296182
Dog
thioredoxin related transmembrane protein 4
VGNC:47645
477161
Horse
thioredoxin related transmembrane protein 4
VGNC:24355
100065101
Species
Name
OMA
EggNOG
Inparanoid
Macaque
thioredoxin related transmembrane protein 4
Mouse
Rat
Dog
thioredoxin related transmembrane protein 4
Horse
thioredoxin related transmembrane protein 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H1E5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (56)
1 – 10 of 56
IL27RA
Tbio
Novelty: 0.01348051
p_int: 0.99958574
p_ni: 0.00041426
Data Source: BioPlex
BTN2A1
Tbio
Novelty: 0.02259329
p_int: 0.998066269
p_ni: 0.001933731
Data Source: BioPlex
ADGRG5
Tdark
Family: GPCR
Novelty: 0.26575982
p_int: 0.997580618
p_ni: 0.002419382
Data Source: BioPlex
VASN
Tbio
Novelty: 0.05424159
p_int: 0.997339875
p_ni: 0.002660125
Data Source: BioPlex
CD226
Tbio
Novelty: 0.00374102
p_int: 0.995188152
p_ni: 0.004811848
Data Source: BioPlex
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00410031
p_int: 0.984847467
p_ni: 0.015152532
p_wrong: 1e-9
Data Source: BioPlex
IFNLR1
Tbio
Novelty: 0.01990628
p_int: 0.982471348
p_ni: 0.017528652
Data Source: BioPlex
ZACN
Tchem
Family: IC
Novelty: 0.21891621
p_int: 0.973066466
p_ni: 0.026933534
Data Source: BioPlex
CSGALNACT2
Tbio
Family: Enzyme
Novelty: 0.0770692
p_int: 0.963909026
p_ni: 0.036090648
p_wrong: 3.26e-7
Data Source: BioPlex
EREG
Tbio
Novelty: 0.00371897
p_int: 0.949066073
p_ni: 0.050933927
Score: 0.28
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.46

PubMed score by year
PubTator Score  2.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer