You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SH2D3A
SH2 domain-containing protein 3A

Protein Summary
Description
May play a role in JNK activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245908
  • ENSP00000245908
  • ENSG00000125731
  • ENST00000437152
  • ENSP00000393303

Symbol
  • NSP1
  • NSP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.71
hub protein
0.58
small molecule perturbation
0.53
cellular component
0.5
tissue sample
0.48


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 532.35   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 532.35   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 3A
VGNC:2251
468688
Macaque
SH2 domain containing 3A
704052
Dog
SH2 domain containing 3A
VGNC:46112
485017
Horse
SH2 domain containing 3A
VGNC:22928
100065982
Cow
SH2 domain containing 3A
VGNC:34558
510173
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 3A
Macaque
SH2 domain containing 3A
Dog
SH2 domain containing 3A
Horse
SH2 domain containing 3A
Cow
SH2 domain containing 3A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BRG2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (50)
1 – 10 of 50
PRSS57
Tbio
Family: Enzyme
Novelty: 0.00250647
Score: 0.955
Data Source: STRINGDB
SPECC1
Tbio
Novelty: 0.00830299
Score: 0.921
Data Source: STRINGDB
BCAR1
Tbio
Novelty: 0.00329214
Score: 0.813
Data Source: STRINGDB
MRPL58
Tbio
Family: Enzyme
Novelty: 0.00178011
Score: 0.796
Data Source: STRINGDB
BAG6
Tbio
Novelty: 0.0035578
Score: 0.796
Data Source: STRINGDB
C6orf48
Tdark
Novelty: 0.00615017
Score: 0.732
Data Source: STRINGDB
NUTF2
Tbio
Novelty: 0.00334688
Score: 0.707
Data Source: STRINGDB
MAVS
Tbio
Novelty: 0.00241215
Score: 0.695
Data Source: STRINGDB
PIH1D3
Tbio
Novelty: 0.18791294
Score: 0.657
Data Source: STRINGDB
KIR2DL4
Tbio
Novelty: 0.00163053
Score: 0.655
Data Source: STRINGDB
Publication Statistics
PubMed Score  532.35

PubMed score by year
PubTator Score  212.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer