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Tbio
THOC2
THO complex subunit 2

Protein Summary
Description
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. The TREX multiprotein complex binds specifically to spliced ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245838
  • ENSP00000245838
  • ENSG00000125676
  • ENST00000355725
  • ENSP00000347959
  • ENST00000618150
  • ENSP00000480478

Symbol
  • CXorf3
  • THO2
  • MRX12
  • MRX35
  • CXorf3
  • hTREX120
  • dJ506G2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase perturbation
0.81
transcription factor perturbation
0.8
gene perturbation
0.77
hub protein
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.73   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.73   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
94.4
eosinophil count
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
94.4
eosinophil count
1
17.5
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
THO complex 2
VGNC:1520
465844
Macaque
THO complex 2
697668
Mouse
MGI:2442413
331401
Rat
RGD:1561623
313308
Dog
THO complex 2
VGNC:47349
481042
Species
Name
OMA
EggNOG
Inparanoid
Chimp
THO complex 2
Macaque
THO complex 2
Mouse
Rat
Dog
THO complex 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NI27-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (233)
1 – 10 of 233
THOC1
Tbio
Novelty: 0.03702557
p_int: 0.999986235
p_ni: 0.000013765
Score: 0.999
Data Source: BioPlex,STRINGDB
THOC3
Tbio
Novelty: 0.04716962
p_int: 0.999594136
p_ni: 0.000405864
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.753323623
p_ni: 0.246676377
Score: 0.229
Data Source: BioPlex,STRINGDB
THOC5
Tbio
Novelty: 0.04618391
Score: 0.999
Data Source: STRINGDB
NCBP1
Tbio
Novelty: 0.01228885
Score: 0.999
Data Source: STRINGDB
THOC6
Tbio
Novelty: 0.0744541
Score: 0.999
Data Source: STRINGDB
ALYREF
Tbio
Novelty: 0.00523802
Score: 0.999
Data Source: STRINGDB
THOC7
Tbio
Novelty: 0.16971494
Score: 0.999
Data Source: STRINGDB
DDX39B
Tbio
Family: Enzyme
Novelty: 0.012548
Score: 0.999
Data Source: STRINGDB
DDX39A
Tbio
Family: Enzyme
Novelty: 0.0373703
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.73

PubMed score by year
PubTator Score  55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer