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Tbio
NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

Protein Summary
Description
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245552
  • ENSP00000245552
  • ENSG00000125458
  • ENST00000580758
  • ENSP00000462123

Symbol
  • DNT1
  • UMPH2
  • DNT
  • cdN
  • DNT1
  • P5N2
  • PN-I
  • HEL74
  • PN-II
  • UMPH2
  • dNT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
cell type or tissue
0.69
cell line
0.65
molecular function
0.63
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.9   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.9   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
75.5
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Purine catabolism
Reactome
Pyrimidine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Purine catabolism
Pyrimidine catabolism
Protein-Protein Interactions (141)
1 – 10 of 141
ARPC1B
Tbio
Novelty: 0.03873325
p_int: 0.99905129
p_ni: 0.00094871
Score: 0.568
Data Source: BioPlex,STRINGDB
FLNC
Tbio
Novelty: 0.00463205
p_int: 0.960066526
p_ni: 0.039933474
Score: 0.16
Data Source: BioPlex,STRINGDB
FAAP20
Tbio
Novelty: 0.15112645
p_int: 0.899219992
p_ni: 0.100780006
p_wrong: 1e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
ZNF581
Tdark
Family: TF
Novelty: 18
p_int: 0.89707841
p_ni: 0.102880195
p_wrong: 0.000041395
Score: 0.242
Data Source: BioPlex,STRINGDB
SIRPD
Tdark
Novelty: 4.75114214
p_int: 0.776472105
p_ni: 0.223527314
p_wrong: 5.81e-7
Score: 0.309
Data Source: BioPlex,STRINGDB
RAP1GDS1
Tbio
Family: Enzyme
Novelty: 0.06140479
p_int: 0.754584014
p_ni: 0.245415986
Score: 0.183
Data Source: BioPlex,STRINGDB
NT5C3A
Tbio
Family: Enzyme
Novelty: 0.01939545
Score: 0.979
Data Source: STRINGDB
TYMP
Tclin
Family: Enzyme
Novelty: 0.0015906
Score: 0.946
Data Source: STRINGDB
NT5C1A
Tbio
Family: Enzyme
Novelty: 0.00634411
Score: 0.944
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  140.90

PubMed score by year
PubTator Score  116.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer