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Tbio
NUP85
Nuclear pore complex protein Nup85

Protein Summary
Description
Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872). The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356). NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708). Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708). This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245544
  • ENSP00000245544
  • ENSG00000125450

Symbol
  • NUP75
  • PCNT1
  • Nup75
  • FROUNT
  • NPHS17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.91
virus perturbation
0.88
kinase perturbation
0.84
cellular component
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.67   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.67   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
87.7
waist-hip ratio
1
1
1
65.8
1
1
0
1.2
31
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
87.7
waist-hip ratio
1
65.8
0
1.2
31
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (83)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 81
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (309)
1 – 10 of 309
NUP43
Tbio
Novelty: 0.11571309
p_int: 0.999794211
p_ni: 0.000205789
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP133
Tbio
Novelty: 0.02115225
p_int: 0.998413864
p_ni: 0.001586136
Score: 0.999
Data Source: BioPlex,STRINGDB
SEC13
Tbio
Novelty: 0.00709413
p_int: 0.997106669
p_ni: 0.002893331
Score: 0.999
Data Source: BioPlex,STRINGDB
UXS1
Tbio
Family: Enzyme
Novelty: 0.04671281
p_int: 0.964902824
p_ni: 0.035097176
Data Source: BioPlex
CCDC183
Tdark
Novelty: 1.55719016
p_int: 0.945432926
p_ni: 0.054567074
Data Source: BioPlex
VASN
Tbio
Novelty: 0.05424159
p_int: 0.942562448
p_ni: 0.057437552
Data Source: BioPlex
CD70
Tbio
Novelty: 0.00420393
p_int: 0.937202647
p_ni: 0.062797353
Data Source: BioPlex
PNKD
Tbio
Family: Enzyme
Novelty: 0.02456078
p_int: 0.862001111
p_ni: 0.137998889
Data Source: BioPlex
ENPP6
Tbio
Family: Enzyme
Novelty: 0.06933544
p_int: 0.775650835
p_ni: 0.224349165
Score: 0.187
Data Source: BioPlex,STRINGDB
SPAST
Tbio
Novelty: 0.00303236
p_int: 0.772363218
p_ni: 0.227636782
Score: 0.597
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  42.67

PubMed score by year
PubTator Score  9.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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