You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PIWIL1
Piwi-like protein 1

Protein Summary
Description
Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during mei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245255
  • ENSP00000245255
  • ENSG00000125207
  • ENST00000613226
  • ENSP00000481042
  • ENSG00000275051
  • ENST00000632888
  • ENSP00000487688

Symbol
  • HIWI
  • HIWI
  • MIWI
  • PIWI
  • CT80.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.8
cellular component
0.66
protein domain
0.58
cell type or tissue
0.57
PubMedID
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1061.8   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1061.8   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
piwi like RNA-mediated gene silencing 1
VGNC:13340
452369
Macaque
piwi like RNA-mediated gene silencing 1
708908
Mouse
MGI:1928897
57749
Rat
RGD:1306980
363912
Dog
piwi like RNA-mediated gene silencing 1
VGNC:44592
477440
Species
Name
OMA
EggNOG
Inparanoid
Chimp
piwi like RNA-mediated gene silencing 1
Macaque
piwi like RNA-mediated gene silencing 1
Mouse
Rat
Dog
piwi like RNA-mediated gene silencing 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96J94-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Gene Ontology Terms (22)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (123)
1 – 10 of 123
TDRD6
Tdark
Family: Epigenetic
Novelty: 0.06480806
Score: 0.987
Data Source: Reactome,STRINGDB
TDRKH
Tbio
Family: Epigenetic
Novelty: 0.0875409
Score: 0.984
Data Source: Reactome,STRINGDB
HENMT1
Tdark
Family: Enzyme
Novelty: 0.17427834
Score: 0.977
Data Source: Reactome,STRINGDB
MAEL
Tbio
Novelty: 0.01925239
Score: 0.968
Data Source: STRINGDB
TDRD1
Tbio
Family: Epigenetic
Novelty: 0.04645566
Score: 0.966
Data Source: STRINGDB
MOV10L1
Tbio
Family: Enzyme
Novelty: 0.09735465
Score: 0.962
Data Source: STRINGDB
TDRD7
Tbio
Family: Epigenetic
Novelty: 0.03580848
Score: 0.961
Data Source: STRINGDB
TDRD9
Tbio
Family: Epigenetic
Novelty: 0.10913126
Score: 0.953
Data Source: STRINGDB
DICER1
Tbio
Family: Enzyme
Novelty: 0.000306
Score: 0.944
Data Source: STRINGDB
DDX4
Tbio
Family: Enzyme
Novelty: 0.00692586
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  1061.80

PubMed score by year
PubTator Score  329.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer