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Tbio
EREG
Proepiregulin

Protein Summary
Description
Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244869
  • ENSP00000244869
  • ENSG00000124882

Symbol
  • ER
  • Ep
  • EPR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.98
PubMedID
0.77
microRNA
0.7
histone modification site profile
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.93   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.93   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epiregulin
VGNC:10858
740028
Mouse
MGI:107508
13874
Rat
RGD:620299
59325
Horse
epiregulin
VGNC:17659
100056605
Cow
epiregulin
VGNC:28575
100295476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epiregulin
Mouse
Rat
Horse
epiregulin
Cow
epiregulin
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14944-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (179)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 48
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Gene Ontology Terms (46)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (97)
1 – 10 of 97
RAB4A
Tbio
Family: Enzyme
Novelty: 0.00423197
p_int: 0.986377374
p_ni: 0.011467036
p_wrong: 0.00215559
Score: 0.461
Data Source: BioPlex,STRINGDB
TMX4
Tdark
Novelty: 0.2628295
p_int: 0.949066073
p_ni: 0.050933927
Score: 0.28
Data Source: BioPlex,STRINGDB
LGALS1
Tchem
Novelty: 0.00106509
p_int: 0.822335311
p_ni: 0.177635592
p_wrong: 0.000029097
Score: 0.377
Data Source: BioPlex,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.998
Data Source: Reactome,STRINGDB
HBEGF
Tbio
Novelty: 0.00105355
Score: 0.982
Data Source: Reactome,STRINGDB
ERBB4
Tclin
Family: Kinase
Novelty: 0.00112919
Score: 0.98
Data Source: Reactome,STRINGDB
ERBB3
Tclin
Family: Kinase
Novelty: 0.000868
Score: 0.966
Data Source: Reactome,STRINGDB
NRG2
Tbio
Novelty: 0.01986994
Score: 0.964
Data Source: Reactome,STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.964
Data Source: Reactome,STRINGDB
NRG4
Tbio
Novelty: 0.02484999
Score: 0.961
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  251.93

PubMed score by year
PubTator Score  66.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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