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Tbio
TREM1
Triggering receptor expressed on myeloid cells 1

Protein Summary
Description
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244709
  • ENSP00000244709
  • ENSG00000124731
  • ENST00000334475
  • ENSP00000334284
  • ENST00000591620
  • ENSP00000465345

Symbol
  • CD354
  • TREM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
biological term
0.79
biological process
0.71
cell type or tissue
0.71
microRNA
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.97   (req: < 5)
Gene RIFs: 152   (req: <= 3)
Antibodies: 648   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.97   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 648   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (211)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
DAP12 interactions
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
DAP12 interactions
Hemostasis
Immune System
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (107)
1 – 10 of 107
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00410031
Score: 0.989
Data Source: Reactome,STRINGDB
TREM2
Tbio
Novelty: 0.00228007
Score: 0.918
Data Source: STRINGDB
TREML2
Tbio
Novelty: 0.05038302
Score: 0.901
Data Source: STRINGDB
TREML1
Tbio
Novelty: 0.03513416
Score: 0.805
Data Source: STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.783
Data Source: STRINGDB
FPR1
Tchem
Family: GPCR
Novelty: 0.00256884
Score: 0.783
Data Source: STRINGDB
TLR2
Tchem
Novelty: 0.00023242
Score: 0.721
Data Source: STRINGDB
CLEC5A
Tbio
Novelty: 0.01710591
Score: 0.696
Data Source: STRINGDB
IL1B
Tclin
Novelty: 0.0000308
Score: 0.679
Data Source: STRINGDB
TLR8
Tchem
Novelty: 0.0023384
Score: 0.676
Data Source: STRINGDB
Publication Statistics
PubMed Score  486.97

PubMed score by year
PubTator Score  244.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer