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Tbio
HIST1H1A
Histone H1.1

Protein Summary
Description
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244573
  • ENSP00000244573
  • ENSG00000124610

Symbol
  • H1F1
  • H1A
  • H1.1
  • H1F1
  • HIST1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
tissue sample
0.8
protein complex
0.71
cellular component
0.64
hub protein
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 809.72   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 809.72   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member a
VGNC:14359
471874
Mouse
MGI:1931523
80838
Rat
RGD:1305706
291145
Dog
histone H1.1
488258
Horse
histone H1.1
100052966
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member a
Mouse
Rat
Dog
histone H1.1
Horse
histone H1.1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q02539-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (200)
1 – 10 of 200
RNF151
Tdark
Novelty: 2.0077961
p_int: 0.999999457
p_ni: 5.43e-7
Data Source: BioPlex
RPL28
Tbio
Novelty: 0.03136035
p_int: 0.999999153
p_ni: 8.47e-7
Data Source: BioPlex
ZNF71
Tdark
Family: TF
Novelty: 0.24703192
p_int: 0.999998739
p_ni: 0.000001261
Score: 0.151
Data Source: BioPlex,STRINGDB
ZCRB1
Tdark
Novelty: 0.37592387
p_int: 0.999998539
p_ni: 0.000001461
Score: 0.56
Data Source: BioPlex,STRINGDB
EBNA1BP2
Tbio
Novelty: 0.02083466
p_int: 0.999997922
p_ni: 0.000002078
Data Source: BioPlex
RPS26P11
Tdark
p_int: 0.999997916
p_ni: 0.000002071
p_wrong: 1.3e-8
Data Source: BioPlex
STAU1
Tbio
Novelty: 0.00565778
p_int: 0.999996331
p_ni: 0.000003669
Score: 0.223
Data Source: BioPlex,STRINGDB
CNBP
Tbio
Novelty: 0.00404247
p_int: 0.999994251
p_ni: 0.000005748
p_wrong: 2e-9
Data Source: BioPlex
H1FOO
Tbio
Novelty: 0.02189067
p_int: 0.999984534
p_ni: 0.000015466
Score: 0.664
Data Source: BioPlex,STRINGDB
RBMX2
Tbio
Novelty: 0.08867468
p_int: 0.99998356
p_ni: 0.000016439
Data Source: BioPlex
Publication Statistics
PubMed Score  809.72

PubMed score by year
PubTator Score  176.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer