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Tchem
PTGIS
Prostacyclin synthase

Protein Summary
Description
Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244043
  • ENSP00000244043
  • ENSG00000124212

Symbol
  • CYP8
  • CYP8A1
  • CYP8
  • PGIS
  • PTGI
  • CYP8A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
gene perturbation
0.85
cellular component
0.77
disease
0.77
microRNA
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.43   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.43   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.1
71.7
neuroticism measurement
1
1
1
40.8
wellbeing measurement
1
1
1
39
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
71.7
neuroticism measurement
1
40.8
wellbeing measurement
1
39
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Bile acid and bile salt metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Eicosanoids
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Bile acid and bile salt metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Eicosanoids
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (59)
1 – 10 of 59
PTGS1
Tclin
Family: Enzyme
Novelty: 0.00043214
Score: 0.981
Data Source: STRINGDB
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00007089
Score: 0.974
Data Source: STRINGDB
TBXAS1
Tchem
Family: Enzyme
Novelty: 0.0053649
Score: 0.973
Data Source: STRINGDB
PTGES
Tchem
Family: Enzyme
Novelty: 0.00146096
Score: 0.966
Data Source: STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
Score: 0.954
Data Source: STRINGDB
PTGDS
Tchem
Family: Enzyme
Novelty: 0.002111
Score: 0.953
Data Source: STRINGDB
PTGES3
Tbio
Family: Enzyme
Novelty: 0.0082783
Score: 0.946
Data Source: STRINGDB
HPGDS
Tchem
Family: Enzyme
Novelty: 0.00019629
Score: 0.925
Data Source: STRINGDB
PPP1R3C
Tbio
Family: Enzyme
Novelty: 0.01784199
Score: 0.788
Data Source: STRINGDB
PPP1R3B
Tbio
Family: Enzyme
Novelty: 0.0244434
Score: 0.788
Data Source: STRINGDB
Publication Statistics
PubMed Score  548.43

PubMed score by year
PubTator Score  217.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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