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Tbio
ACTR5
Actin-related protein 5

Protein Summary
Description
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243903
  • ENSP00000243903
  • ENSG00000101442

Symbol
  • ARP5
  • Arp5
  • INO80M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
cellular component
0.77
hub protein
0.75
kinase perturbation
0.71
biological process
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.29   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.29   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
35.4
depressive symptom measurement
1
1
1
6.1
1
1
0
1.1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
35.4
depressive symptom measurement
1
6.1
0
1.1
1.9
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
DNA Damage Recognition in GG-NER (R-HSA-5696394)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Global Genome Nucleotide Excision Repair (GG-NER)
Metabolism of proteins
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (91)
1 – 10 of 91
INO80C
Tdark
Novelty: 0.04242834
p_int: 0.999999993
p_ni: 7e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
RUVBL2
Tbio
Novelty: 0.01129017
p_int: 0.999999899
p_ni: 1e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RUVBL1
Tbio
Novelty: 0.0089115
p_int: 0.999999863
p_ni: 1.37e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
INO80
Tbio
Family: Enzyme
Novelty: 0.09412936
p_int: 0.999999564
p_ni: 4.36e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
UCHL5
Tbio
Family: Enzyme
Novelty: 0.01486265
p_int: 0.999999132
p_ni: 8.68e-7
Score: 0.957
Data Source: BioPlex,STRINGDB
WBP2NL
Tbio
Novelty: 0.03957932
p_int: 0.9999741
p_ni: 0.000025884
p_wrong: 1.6e-8
Score: 0.534
Data Source: BioPlex,STRINGDB
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.999963661
p_ni: 0.000035706
p_wrong: 6.33e-7
Score: 0.192
Data Source: BioPlex,STRINGDB
INO80E
Tdark
Novelty: 0.38735443
Score: 0.999
Data Source: STRINGDB
NFRKB
Tbio
Novelty: 0.13445983
Score: 0.999
Data Source: STRINGDB
ACTR8
Tbio
Novelty: 0.12366847
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.29

PubMed score by year
PubTator Score  3.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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