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Tchem
FAAH
Fatty-acid amide hydrolase 1

Protein Summary
Description
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243167
  • ENSP00000243167
  • ENSG00000117480

Symbol
  • FAAH1
  • PSAB
  • FAAH-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
biological term
0.8
cell type or tissue
0.8
histone modification site profile
0.73
transcription factor perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 716.22   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 716.22   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1020
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
amperozide
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid amide hydrolase
VGNC:10620
456559
Macaque
fatty-acid amide hydrolase 1
708660
Mouse
MGI:109609
14073
Rat
RGD:6491947
100911581
Dog
fatty-acid amide hydrolase 1
482510
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid amide hydrolase
Macaque
fatty-acid amide hydrolase 1
Mouse
Rat
Dog
fatty-acid amide hydrolase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00519-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (97)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (77)
1 – 10 of 77
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.956
Data Source: STRINGDB
NAPEPLD
Tbio
Family: Enzyme
Novelty: 0.00755191
Score: 0.956
Data Source: STRINGDB
MGLL
Tchem
Family: Enzyme
Novelty: 0.00196912
Score: 0.935
Data Source: STRINGDB
CNR2
Tchem
Family: GPCR
Novelty: 0.00215391
Score: 0.922
Data Source: STRINGDB
GATB
Tbio
Family: Enzyme
Novelty: 0.01269151
Score: 0.874
Data Source: STRINGDB
TRPV1
Tclin
Family: IC
Novelty: 0.00039493
Score: 0.867
Data Source: STRINGDB
ABHD6
Tchem
Family: Enzyme
Novelty: 0.019314
Score: 0.845
Data Source: STRINGDB
ABHD12
Tchem
Family: Enzyme
Novelty: 0.02587535
Score: 0.82
Data Source: STRINGDB
GPR55
Tclin
Family: GPCR
Novelty: 0.00428199
Score: 0.806
Data Source: STRINGDB
FABP5
Tchem
Novelty: 0.00570755
Score: 0.804
Data Source: STRINGDB
Publication Statistics
PubMed Score  716.22

PubMed score by year
PubTator Score  463.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer