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Tbio
ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Protein Summary
Description
Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms. This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242592
  • ENSP00000242592
  • ENSG00000122971

Symbol
  • SCAD
  • ACAD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
small molecule perturbation
0.75
protein domain
0.73
kinase perturbation
0.71
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.33   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.33   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Beta oxidation of butanoyl-CoA to acetyl-CoA (R-HSA-77352)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta oxidation of butanoyl-CoA to acetyl-CoA
Reactome
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Beta oxidation of butanoyl-CoA to acetyl-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Fatty acid metabolism
Metabolism
Metabolism of lipids
Protein-Protein Interactions (105)
1 – 10 of 105
DPEP1
Tclin
Family: Enzyme
Novelty: 0.0033193
p_int: 0.998813817
p_ni: 0.001183017
p_wrong: 0.000003166
Score: 0.152
Data Source: BioPlex,STRINGDB
SEC22C
Tdark
Novelty: 1.2
p_int: 0.993387637
p_ni: 0.006612363
Score: 0.455
Data Source: BioPlex,STRINGDB
RING1
Tbio
Family: Enzyme
Novelty: 0.00497005
p_int: 0.963736391
p_ni: 0.036263604
p_wrong: 5e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
LYRM2
Tdark
Novelty: 0.4
p_int: 0.949449933
p_ni: 0.050550067
Score: 0.19
Data Source: BioPlex,STRINGDB
STX5
Tbio
Novelty: 0.01314285
p_int: 0.924478598
p_ni: 0.075521402
Score: 0.166
Data Source: BioPlex,STRINGDB
KIF6
Tbio
Novelty: 0.02906895
p_int: 0.901470495
p_ni: 0.098529505
Score: 0.209
Data Source: BioPlex,STRINGDB
ESS2
Tbio
Novelty: 0.0015116
p_int: 0.809639835
p_ni: 0.190360165
Score: 0.224
Data Source: BioPlex,STRINGDB
SUN2
Tbio
Novelty: 0.01877097
p_int: 0.755023506
p_ni: 0.244976494
Score: 0.214
Data Source: BioPlex,STRINGDB
ECHS1
Tbio
Family: Enzyme
Novelty: 0.01956365
Score: 0.99
Data Source: STRINGDB
ACAA2
Tbio
Family: Enzyme
Novelty: 0.02112232
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  266.33

PubMed score by year
PubTator Score  96.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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