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Tbio
UNG
Uracil-DNA glycosylase

Protein Summary
Description
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242576
  • ENSP00000242576
  • ENSG00000076248
  • ENST00000336865
  • ENSP00000337398

Symbol
  • DGU
  • UNG1
  • UNG15
  • DGU
  • UDG
  • UNG1
  • UNG2
  • HIGM4
  • HIGM5
  • UNG15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
transcription factor perturbation
0.84
PubMedID
0.82
disease
0.79
hub protein
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.64   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 459   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.64   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 459   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uracil DNA glycosylase
VGNC:5644
452217
Macaque
uracil DNA glycosylase
706816
Mouse
MGI:109352
22256
Rat
RGD:1307200
304577
Dog
uracil DNA glycosylase
VGNC:48147
486315
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uracil DNA glycosylase
Macaque
uracil DNA glycosylase
Mouse
Rat
Dog
uracil DNA glycosylase
Protein Data Bank (20)
1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged pyrimidine
Reactome
DNA Repair
Reactome
Depyrimidination
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged pyrimidine
DNA Repair
Depyrimidination
Protein-Protein Interactions (216)
1 – 10 of 216
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
p_int: 0.999989577
p_ni: 3.5e-8
p_wrong: 0.000010388
Score: 0.222
Data Source: BioPlex,STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.973
Data Source: STRINGDB
DUT
Tchem
Family: Enzyme
Novelty: 0.0026993
Score: 0.958
Data Source: STRINGDB
DDB1
Tbio
Novelty: 0.00345896
Score: 0.931
Data Source: STRINGDB
TYMS
Tclin
Family: Enzyme
Novelty: 0.00087522
Score: 0.92
Data Source: STRINGDB
APEX1
Tchem
Family: Enzyme
Novelty: 0.00037532
Score: 0.913
Data Source: Reactome,STRINGDB
LIG1
Tchem
Family: Enzyme
Novelty: 0.00326816
Score: 0.908
Data Source: STRINGDB
OGG1
Tbio
Family: Enzyme
Novelty: 0.00074509
Score: 0.903
Data Source: STRINGDB
FEN1
Tchem
Family: Enzyme
Novelty: 0.00082515
Score: 0.895
Data Source: STRINGDB
NTHL1
Tbio
Family: Enzyme
Novelty: 0.00769394
Score: 0.893
Data Source: STRINGDB
Publication Statistics
PubMed Score  334.64

PubMed score by year
PubTator Score  462.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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