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Tbio
HOXA7
Homeobox protein Hox-A7

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242159
  • ENSP00000242159
  • ENSG00000122592

Symbol
  • HOX1A
  • ANTP
  • HOX1
  • HOX1A
  • HOX1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
biological process
0.9
protein domain
0.85
molecular function
0.81
transcription factor
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 292.57   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 292.57   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox A7
745634
Macaque
homeobox A7
699858
Mouse
MGI:96179
15404
Dog
homeobox A7
VGNC:49910
482371
Horse
homeobox A7
VGNC:18841
100054532
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox A7
Macaque
homeobox A7
Mouse
Dog
homeobox A7
Horse
homeobox A7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P31268-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (21)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (74)
1 – 10 of 74
HOXA6
Tbio
Family: TF
Novelty: 0.04558872
Score: 0.978
Data Source: STRINGDB
HOXA5
Tbio
Family: TF
Novelty: 0.0058504
Score: 0.976
Data Source: STRINGDB
HOXB6
Tbio
Family: TF
Novelty: 0.0176813
Score: 0.969
Data Source: STRINGDB
HOXB5
Tbio
Family: TF
Novelty: 0.01119871
Score: 0.969
Data Source: STRINGDB
HOXB4
Tbio
Family: TF
Novelty: 0.00598207
Score: 0.968
Data Source: STRINGDB
HOXD4
Tbio
Family: TF
Novelty: 0.01675267
Score: 0.968
Data Source: STRINGDB
HOXC6
Tbio
Family: TF
Novelty: 0.00991192
Score: 0.968
Data Source: STRINGDB
HOXC5
Tbio
Family: TF
Novelty: 0.05354226
Score: 0.967
Data Source: STRINGDB
HOXC4
Tbio
Family: TF
Novelty: 0.02206351
Score: 0.966
Data Source: STRINGDB
HOXB7
Tbio
Family: TF
Novelty: 0.00765378
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  292.57

PubMed score by year
PubTator Score  84.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer