Tbio MYOG Myogenin

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Myogenin

Protein / Nucleic Acid Binding / Myogenin

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Myogenin

Protein Summary

Description

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity). Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15173
• Q53XW6

Gene Name

• MYOG

Ensembl ID

• ENST00000241651
• ENSP00000241651
• ENSG00000122180

Symbol

• BHLHC3
• MYF4
• MYF4
• myf-4
• bHLHc3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
molecular function	0.95
gene perturbation	0.65
tissue	0.65
cellular component	0.64

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 872   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 1009   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 872   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 1009   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (7)

Reactome (2)

PathwayCommons (2)

WikiPathways (3)

Developmental Biology (R-HSA-1266738)

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Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Myogenesis	29 targets	R-HSA-525793

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Myogenesis	29 targets	R-HSA-525793

Gene Ontology Terms (49)

Functions (11)

Components (4)

Processes (34)

Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chromatin DNA binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
DNA-binding transcription factor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
E-box binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein heterodimerization activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB

Protein-Protein Interactions (220)

Explore Interacting Targets

1 – 10 of 220

• See Interactions on String-DB

TCF12

Tbio

Family: TF

Novelty: 0.00546341

p_int: 0.999990796

p_ni: 0.000009204

Score: 0.991

Data Source: BioPlex,STRINGDB

TCF4

Tbio

Family: TF

Novelty: 0.00249816

p_int: 0.999944702

p_ni: 0.00005529

p_wrong: 8e-9

Score: 0.989

Data Source: BioPlex,STRINGDB

TCF3

Tbio

Family: TF

Novelty: 0.00154157

p_int: 0.978505325

p_ni: 0.021494674

p_wrong: 1e-9

Score: 0.992

Data Source: BioPlex,Reactome,STRINGDB

NES

Tbio

Novelty: 0.00038894

p_int: 0.843885118

p_ni: 0.020879581

p_wrong: 0.135235301

Score: 0.778

Data Source: BioPlex,STRINGDB

ID4

Tbio

Family: TF

Novelty: 0.00570969

p_int: 0.782555675

p_ni: 0.000538307

p_wrong: 0.216906018

Score: 0.838

Data Source: BioPlex,STRINGDB

MEF2C

Tbio

Family: TF

Novelty: 0.00288254

Score: 0.988

Data Source: Reactome,STRINGDB

MEF2A

Tbio

Family: TF

Novelty: 0.00521515

Score: 0.988

Data Source: Reactome,STRINGDB

MEF2D

Tbio

Family: TF

Novelty: 0.008552

Score: 0.98

Data Source: STRINGDB

MYOD1

Tbio

Family: TF

Novelty: 0.00064991

Score: 0.947

Data Source: STRINGDB

PAX7

Tbio

Family: TF

Novelty: 0.0018427

Score: 0.945

Data Source: STRINGDB

Publication Statistics

PubMed Score  872.00

PubMed score by year

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PubTator Score  524.88

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MELYETSPYFYQEPRFYDGENYLPVHLQGFEPPGYERTELTLSPEAPGPLEDKGLGTPEHCPGQCLPWAC

1-70

KVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLN

70-140

QEERDLRYRGGGGPQPGVPSECSSHSASCSPEWGSALEFSANPGDHLLTADPTDAHNLHSLTSIVDSITV

140-210

EDVSVAFPDETMPN

210-224

MELYETSPYFYQEPRFYDGENYLPVHLQGFEPPGYERTELTLSPEAPGPLEDKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPGVPSECSSHSASCSPEWGSALEFSANPGDHLLTADPTDAHNLHSLTSIVDSITVEDVSVAFPDETMPN

Find similar targets by:

Uniprot Keyword

Activator
Cell cycle
Complete proteome
Developmental protein
Differentiation
DNA-binding
Myogenesis
Nucleus
Phosphoprotein
Reference proteome