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Tclin
FLT3
Receptor-type tyrosine-protein kinase FLT3

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane lea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241453
  • ENSP00000241453
  • ENSG00000122025

Symbol
  • CD135
  • FLK2
  • STK1
  • FLK2
  • STK1
  • CD135
  • FLK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
biological process
0.98
small molecule
0.95
biological term
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3132.13   (req: < 5)
Gene RIFs: 537   (req: <= 3)
Antibodies: 1452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3132.13   (req: >= 5)
Gene RIFs: 537   (req: > 3)
Antibodies: 1452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 551
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
Approved Drugs (12)
1 – 10 of 12
sunitinib
chemical structure image
sorafenib
chemical structure image
nintedanib
chemical structure image
midostaurin
chemical structure image
quizartinib
chemical structure image
cabozantinib
chemical structure image
ponatinib
chemical structure image
fedratinib
chemical structure image
ceritinib
chemical structure image
gilteritinib
chemical structure image
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
4
6
96.9
monocyte count
5
6
8
95
myeloid white cell count
2
3
4
90.9
neutrophil count
3
5
6
90.6
monocyte percentage of leukocytes
2
7
8
79.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
96.9
monocyte count
8
95
myeloid white cell count
4
90.9
neutrophil count
6
90.6
monocyte percentage of leukocytes
8
79.4
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (32)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
IGF1R signaling cascade
Reactome
IRS-mediated signalling
Reactome
IRS-related events triggered by IGF1R
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
IGF1R signaling cascade
IRS-mediated signalling
IRS-related events triggered by IGF1R
Gene Ontology Terms (48)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (313)
1 – 10 of 313
FLT3LG
Tbio
Family: Enzyme
Novelty: 0.00416025
Score: 0.997
Data Source: Reactome,STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.971
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.97
Data Source: STRINGDB
SPI1
Tbio
Family: TF
Novelty: 0.00064309
Score: 0.969
Data Source: STRINGDB
CEBPA
Tbio
Family: TF
Novelty: 0.00056459
Score: 0.961
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.956
Data Source: STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.949
Data Source: Reactome,STRINGDB
KITLG
Tbio
Novelty: 0.00036337
Score: 0.948
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.941
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  3132.13

PubMed score by year
PubTator Score  1768.71

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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