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Tchem
PANK3
Pantothenate kinase 3

Protein Summary
Description
Plays a role in the physiological regulation of the intracellular CoA concentration. This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239231
  • ENSP00000239231
  • ENSG00000120137
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
microRNA
0.82
virus perturbation
0.79
transcription factor binding site profile
0.77
histone modification site profile
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.67   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.67   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3410246
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pantothenate kinase 3
VGNC:4117
462250
Macaque
pantothenate kinase 3
100427204
Mouse
MGI:2387464
211347
Rat
RGD:1310531
360511
Dog
pantothenate kinase 3
VGNC:44252
489133
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pantothenate kinase 3
Macaque
pantothenate kinase 3
Mouse
Rat
Dog
pantothenate kinase 3
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H999-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Coenzyme A biosynthesis (R-HSA-196783)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Coenzyme A biosynthesis
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B5 (pantothenate) metabolism
Name
Explore in Pharos
Explore in Source
Coenzyme A biosynthesis
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B5 (pantothenate) metabolism
Protein-Protein Interactions (26)
1 – 10 of 26
PANK2
Tbio
Family: Kinase
Novelty: 0.00465551
p_int: 0.999999997
p_wrong: 3e-9
Data Source: BioPlex
COASY
Tbio
Family: Enzyme
Novelty: 0.00294867
Score: 0.977
Data Source: STRINGDB
PPCS
Tbio
Family: Enzyme
Novelty: 0.03813202
Score: 0.957
Data Source: STRINGDB
PPCDC
Tbio
Family: Enzyme
Novelty: 0.0322534
Score: 0.956
Data Source: STRINGDB
ENPP3
Tbio
Family: Enzyme
Novelty: 0.00414129
Score: 0.902
Data Source: STRINGDB
ENPP1
Tchem
Family: Enzyme
Novelty: 0.00256132
Score: 0.902
Data Source: STRINGDB
VNN2
Tbio
Novelty: 0.02286648
Score: 0.71
Data Source: STRINGDB
VNN1
Tchem
Family: Enzyme
Novelty: 0.0144646
Score: 0.69
Data Source: STRINGDB
VNN3
Tbio
Novelty: 0.11036559
Score: 0.658
Data Source: STRINGDB
GGA3
Tbio
Novelty: 0.01898553
Score: 0.534
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.67

PubMed score by year
PubTator Score  3.85

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer