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Tchem
DUSP1
Dual specificity protein phosphatase 1

Protein Summary
Description
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239223
  • ENSP00000239223
  • ENSG00000120129

Symbol
  • CL100
  • MKP1
  • PTPN10
  • VH1
  • HVH1
  • MKP1
  • CL100
  • MKP-1
  • PTPN10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
virus perturbation
1
protein domain
0.99
transcription factor binding site profile
0.99
gene perturbation
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1143.44   (req: < 5)
Gene RIFs: 166   (req: <= 3)
Antibodies: 514   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1143.44   (req: >= 5)
Gene RIFs: 166   (req: > 3)
Antibodies: 514   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
55.5
parental genotype effect measurement
1
1
1
50.6
birth weight
1
1
1
50.6
optic cup area measurement
1
1
2
27.8
cup-to-disc ratio measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
55.5
parental genotype effect measurement
1
50.6
birth weight
1
50.6
optic cup area measurement
2
27.8
cup-to-disc ratio measurement
1
15.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 1
VGNC:11934
471742
Mouse
MGI:105120
19252
Rat
RGD:620897
114856
Dog
dual specificity phosphatase 1
VGNC:51892
489117
Horse
dual specificity phosphatase 1
VGNC:17346
100069834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 1
Mouse
Rat
Dog
dual specificity phosphatase 1
Horse
dual specificity phosphatase 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28562-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (55)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAPK family signaling cascades
Reactome
MAPK1/MAPK3 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAPK family signaling cascades
MAPK1/MAPK3 signaling
Gene Ontology Terms (37)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (159)
1 – 10 of 159
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.994
Data Source: STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.992
Data Source: STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.991
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.989
Data Source: STRINGDB
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
Score: 0.963
Data Source: STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00006103
Score: 0.96
Data Source: STRINGDB
NR3C1
Tclin
Family: NR
Novelty: 0.00029396
Score: 0.957
Data Source: STRINGDB
MAPK10
Tchem
Family: Kinase
Novelty: 0.00420573
Score: 0.954
Data Source: STRINGDB
MAPK9
Tchem
Family: Kinase
Novelty: 0.00267199
Score: 0.954
Data Source: STRINGDB
MAPK12
Tchem
Family: Kinase
Novelty: 0.00835017
Score: 0.946
Data Source: STRINGDB
Publication Statistics
PubMed Score  1143.44

PubMed score by year
PubTator Score  466.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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