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Tbio
TGFB3
Transforming growth factor beta-3 proprotein

Protein Summary
Description
Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Latency-associated peptide: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238682
  • ENSP00000238682
  • ENSG00000119699
  • ENST00000556285
  • ENSP00000451110

Symbol
  • ARVD
  • LDS5
  • RNHF
  • ARVD1
  • TGF-beta3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
0.92
disease perturbation
0.9
biological term
0.88
gene perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1445.09   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 434   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1445.09   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 434   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (65)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Elastic fibre formation
Extracellular matrix organization
Hemostasis
Molecules associated with elastic fibres
Gene Ontology Terms (68)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
AgBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (208)
1 – 10 of 208
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00081645
Score: 0.999
Data Source: STRINGDB
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00085381
Score: 0.998
Data Source: STRINGDB
TGFBR3
Tbio
Novelty: 0.0077307
Score: 0.972
Data Source: STRINGDB
CTGF
Tbio
Novelty: 0.0004346
Score: 0.968
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.967
Data Source: STRINGDB
SMAD7
Tbio
Family: TF
Novelty: 0.00116343
Score: 0.966
Data Source: STRINGDB
ENG
Tbio
Novelty: 0.00036729
Score: 0.966
Data Source: STRINGDB
LTBP3
Tbio
Novelty: 0.0190763
Score: 0.962
Data Source: Reactome,STRINGDB
SERPINE1
Tchem
Novelty: 0.00017629
Score: 0.962
Data Source: STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  1445.09

PubMed score by year
PubTator Score  631.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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